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@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix bibo: <http://purl.org/ontology/bibo/> .
@prefix cito: <http://purl.org/spar/cito/> .
@prefix dc: <http://purl.org/dc/elements/1.1/> .
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<http://treatment.plazi.org/id/03F987928955FFEBFC51C6D8FD28FB0B>
cito:cites <http://dx.doi.org/10.5281/zenodo.2554792>, <http://dx.doi.org/10.5281/zenodo.2554800> ;
dc:creator "Chevrette, Marc G.; Carlson, Caitlin M.; Ortega, Humberto E.; Thomas, Chris; Ananiev, Gene E.; Barns, Kenneth J.; Book, Adam J.; Cagnazzo, Julian; Carlos, Camila; Flanigan, Will; Grubbs, Kirk J.; Horn, Heidi A.; Hoffmann, Michael; Klassen, Jonathan L.; Knack, Jennifer J.; Lewin, Gina R.; McDonald, Bradon R.; Mulle, Laura; Melo, Weilan G. P.; Pinto-Tomás, Adrián A.; Schmitz, Amber; Wendt-Pienkowski, Evelyn; Wildman, Scott; Zhao, Miao; Zhang, Fan; Bugni, Tim S.; Andes, David R.; Pupo, Monica T.; Currie, Cameron R." ;
dc:title "Data Walker 1862" ;
trt:augmentsTaxonConcept <http://taxon-concept.plazi.org/id/Animalia/Data_Walker_1862> ;
trt:publishedIn <http://dx.doi.org/10.1038/s41467-019-08438-0> ;
a trt:Treatment .
<http://dx.doi.org/10.1038/s41467-019-08438-0>
bibo:endPage "11" ;
bibo:issue "516" ;
bibo:journal "Nature Communications" ;
bibo:startPage "1" ;
bibo:volume "10" ;
dc:creator "Chevrette, Marc G.; Carlson, Caitlin M.; Ortega, Humberto E.; Thomas, Chris; Ananiev, Gene E.; Barns, Kenneth J.; Book, Adam J.; Cagnazzo, Julian; Carlos, Camila; Flanigan, Will; Grubbs, Kirk J.; Horn, Heidi A.; Hoffmann, Michael; Klassen, Jonathan L.; Knack, Jennifer J.; Lewin, Gina R.; McDonald, Bradon R.; Mulle, Laura; Melo, Weilan G. P.; Pinto-Tomás, Adrián A.; Schmitz, Amber; Wendt-Pienkowski, Evelyn; Wildman, Scott; Zhao, Miao; Zhang, Fan; Bugni, Tim S.; Andes, David R.; Pupo, Monica T.; Currie, Cameron R." ;
dc:date "2019" ;
dc:title "The antimicrobial potential from insect microbiomes of Streptomyces" ;
fabio:hasPart <http://dx.doi.org/10.5281/zenodo.2554792>, <http://dx.doi.org/10.5281/zenodo.2554800> ;
a fabio:JournalArticle .
<http://taxon-concept.plazi.org/id/Animalia/Data_Walker_1862>
dwc:authorityName "Walker" ;
dwc:authorityYear "1862" ;
dwc:class "Insecta" ;
dwc:family "Noctuidae" ;
dwc:genus "Data" ;
dwc:kingdom "Animalia" ;
dwc:order "Lepidoptera" ;
dwc:phylum "Arthropoda" ;
dwc:rank "genus" ;
dwc:scientificNameAuthorship "Walker, 1862" ;
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dwc:class "Insecta" ;
dwc:family "Noctuidae" ;
dwc:genus "Data" ;
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dwc:rank "genus" ;
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dwc:class "Insecta" ;
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dwc:order "Lepidoptera" ;
dwc:phylum "Arthropoda" ;
dwc:rank "order" ;
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dwc:kingdom "Animalia" ;
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<http://dx.doi.org/10.5281/zenodo.2554792>
dc:description "Fig. 1 Sampling strategy for Streptomyces from insect microbiomes. Streptomyces were isolated from a wide range of insects and geographies (1445 insects; 10,178 strains; dot size, insects sampled). Streptomyces production of the antifungal mycangimycin (1) in the Southern Pine Beetle system is shown at right. Cyphomycin (2) is a new antifungal described herein. Photo credits: southern pine beetle - Erich G. Vallery; fungus-growing ant Alexander Wild" ;
fabio:hasRepresentation <https://zenodo.org/record/2554792/files/figure.png> ;
a fabio:Figure .
<http://dx.doi.org/10.5281/zenodo.2554800>
dc:description "Fig. 5 Insect-associated Streptomyces are a source of active antimicrobials. a Fractionated extracts from insect microbiomes are active in multiple murine models of drug-resistant infection. Less infective burden is seen in intraperitoneally treated mice after 8 h of infection. Each dot represents a unique fraction in one mouse study. (n = 15, 11, and 8 for C. albicans, E. coli, and P. aeruginosa models, respectively; center, median; box, upper and lower quantiles; whiskers, 1.5× interquartile range. b Most fractions from insect microbiomes show no hemolysis in cell-based assays. Safe indicates no toxicity at>100× concentration associated with efficacy. c The antifungal cyphomycin is produced by Streptomyces isolated from d the fungus-growing ant Cyphomyrmex sp. Photo credit: Alexander Wild e Cyphomycin-containing fractions show potency against the ant pathogen Escovopsis sp. (top left, bottom). f Purified cyphomycin exhibits potency against resistant pathogens. g Mouse candidiasis (C. albicans) models showcase reduced infection and a dose-like response to cyphomycin. Dots indicate individual mice" ;
fabio:hasRepresentation <https://zenodo.org/record/2554800/files/figure.png> ;
a fabio:Figure .