@prefix rdf: . @prefix rdfs: . @prefix bibo: . @prefix cito: . @prefix dc: . @prefix dwc: . @prefix dwcFP: . @prefix fabio: . @prefix trt: . @prefix xlink: . cito:cites , ; dc:creator "Chevrette, Marc G.; Carlson, Caitlin M.; Ortega, Humberto E.; Thomas, Chris; Ananiev, Gene E.; Barns, Kenneth J.; Book, Adam J.; Cagnazzo, Julian; Carlos, Camila; Flanigan, Will; Grubbs, Kirk J.; Horn, Heidi A.; Hoffmann, Michael; Klassen, Jonathan L.; Knack, Jennifer J.; Lewin, Gina R.; McDonald, Bradon R.; Mulle, Laura; Melo, Weilan G. P.; Pinto-Tomás, Adrián A.; Schmitz, Amber; Wendt-Pienkowski, Evelyn; Wildman, Scott; Zhao, Miao; Zhang, Fan; Bugni, Tim S.; Andes, David R.; Pupo, Monica T.; Currie, Cameron R." ; dc:title "Data Walker 1862" ; trt:augmentsTaxonConcept ; trt:publishedIn ; a trt:Treatment . bibo:endPage "11" ; bibo:issue "516" ; bibo:journal "Nature Communications" ; bibo:startPage "1" ; bibo:volume "10" ; dc:creator "Chevrette, Marc G.; Carlson, Caitlin M.; Ortega, Humberto E.; Thomas, Chris; Ananiev, Gene E.; Barns, Kenneth J.; Book, Adam J.; Cagnazzo, Julian; Carlos, Camila; Flanigan, Will; Grubbs, Kirk J.; Horn, Heidi A.; Hoffmann, Michael; Klassen, Jonathan L.; Knack, Jennifer J.; Lewin, Gina R.; McDonald, Bradon R.; Mulle, Laura; Melo, Weilan G. P.; Pinto-Tomás, Adrián A.; Schmitz, Amber; Wendt-Pienkowski, Evelyn; Wildman, Scott; Zhao, Miao; Zhang, Fan; Bugni, Tim S.; Andes, David R.; Pupo, Monica T.; Currie, Cameron R." ; dc:date "2019" ; dc:title "The antimicrobial potential from insect microbiomes of Streptomyces" ; fabio:hasPart , ; a fabio:JournalArticle . dwc:authorityName "Walker" ; dwc:authorityYear "1862" ; dwc:class "Insecta" ; dwc:family "Noctuidae" ; dwc:genus "Data" ; dwc:kingdom "Animalia" ; dwc:order "Lepidoptera" ; dwc:phylum "Arthropoda" ; dwc:rank "genus" ; dwc:scientificNameAuthorship "Walker, 1862" ; trt:hasTaxonName ; a dwcFP:TaxonConcept . dwc:class "Insecta" ; dwc:family "Noctuidae" ; dwc:genus "Data" ; dwc:kingdom "Animalia" ; dwc:order "Lepidoptera" ; dwc:phylum "Arthropoda" ; dwc:rank "genus" ; trt:hasParentName ; a dwcFP:TaxonName . dwc:class "Insecta" ; dwc:family "Noctuidae" ; dwc:kingdom "Animalia" ; dwc:order "Lepidoptera" ; dwc:phylum "Arthropoda" ; dwc:rank "family" ; trt:hasParentName ; a dwcFP:TaxonName . dwc:class "Insecta" ; dwc:kingdom "Animalia" ; dwc:order "Lepidoptera" ; dwc:phylum "Arthropoda" ; dwc:rank "order" ; trt:hasParentName ; a dwcFP:TaxonName . dwc:class "Insecta" ; dwc:kingdom "Animalia" ; dwc:phylum "Arthropoda" ; dwc:rank "class" ; trt:hasParentName ; a dwcFP:TaxonName . dwc:kingdom "Animalia" ; dwc:phylum "Arthropoda" ; dwc:rank "phylum" ; trt:hasParentName ; a dwcFP:TaxonName . dwc:kingdom "Animalia" ; dwc:rank "kingdom" ; a dwcFP:TaxonName . dc:description "Fig. 1 Sampling strategy for Streptomyces from insect microbiomes. Streptomyces were isolated from a wide range of insects and geographies (1445 insects; 10,178 strains; dot size, insects sampled). Streptomyces production of the antifungal mycangimycin (1) in the Southern Pine Beetle system is shown at right. Cyphomycin (2) is a new antifungal described herein. Photo credits: southern pine beetle - Erich G. Vallery; fungus-growing ant – Alexander Wild" ; fabio:hasRepresentation ; a fabio:Figure . dc:description "Fig. 5 Insect-associated Streptomyces are a source of active antimicrobials. a Fractionated extracts from insect microbiomes are active in multiple murine models of drug-resistant infection. Less infective burden is seen in intraperitoneally treated mice after 8 h of infection. Each dot represents a unique fraction in one mouse study. (n = 15, 11, and 8 for C. albicans, E. coli, and P. aeruginosa models, respectively; center, median; box, upper and lower quantiles; whiskers, 1.5× interquartile range. b Most fractions from insect microbiomes show no hemolysis in cell-based assays. Safe indicates no toxicity at>100× concentration associated with efficacy. c The antifungal cyphomycin is produced by Streptomyces isolated from d the fungus-growing ant Cyphomyrmex sp. Photo credit: Alexander Wild e Cyphomycin-containing fractions show potency against the ant pathogen Escovopsis sp. (top left, bottom). f Purified cyphomycin exhibits potency against resistant pathogens. g Mouse candidiasis (C. albicans) models showcase reduced infection and a dose-like response to cyphomycin. Dots indicate individual mice" ; fabio:hasRepresentation ; a fabio:Figure .