dc:description"Fig. 2. G. lucidum harbours three ceramide synthases. Phylogenetic analysis of ceramide synthases in eukaryotes. The phylogenetic tree was conducted using MEGA 6 and can be roughly divided into three major groups: human, plant and fungi. The evolutionary history was inferred by the neighbour-joining method from 1000 replicates using MEGA 6.";
dc:description"Fig. 1. Overview of the sphingolipid biosynthetic pathway in yeast and filamentous fungi. The abbreviations used are as follows: Dihydroxy LCB: dihydroxy longchain (sphingoid) base; Trihydroxy LCB: trihydroxy long-chain sphingoid base; Long chain FA-CoA: long chain fatty acyl-coenzyme A; Very long chain FA-CoA: very long chain fatty acyl-coenzyme A; IPC synthase: inositol phosphorylceramide synthase; IPC mannosyl transferase: inositol phosphorylceramide mannosyl transferase; MIPCs: mannose inositol phosphorylceramides; M (IP)2Cs: mannose (inositol phosphoryl)2- ceramides.";
dc:description"Fig. 3. Effect of lag gene silencing on G. lucidum growth. Morphology of fungal colonies in lag-silenced, WT and SiControl strains after cultivation in the dark on CYM medium at 28 ̊C for 5 days. Three independent biological replicates in each column. Error bars represent standard deviations, and asterisks show significant differences from control (WT and Sicontrol) strains according to Student's t-test (**P <0.01, n = 3).";
dc:description"Fig. 4. Ganoderic acid biosynthesis in G. lucidum is influenced by the lag gene. A Systematic content analysis of ganoderic acid in the lag-silenced, WT and SiControl strains. B–D Relative gene expression of hmgr (B), sqs (C) and osc (D) in the WT, SiControl and lag-silenced strains. There are three independent biological replicates in each column. Error bars represent standard deviations, and asterisks show significant differences from control (WT and Sicontrol) strains according to Student's t-test (**P <0.01, n = 3).";
