98 lines
10 KiB
XML
98 lines
10 KiB
XML
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<mods:title id="52BC311FECE3CB1B86936EDE2FCC1F34">Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties</mods:title>
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<mods:namePart id="1785EFA3AB287075F4E62989FB18FB6B">Fiorito, Serena</mods:namePart>
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<mods:affiliation id="ECC65FEE5D9A8143FAA69B7DC6F84766">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy & Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia, Italy</mods:affiliation>
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<mods:namePart id="1CBF328780852ECFDD1C91328086D733">Epifano, Francesco</mods:namePart>
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<mods:affiliation id="48487F4F22D4C3529168C5F0DFF495D5">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="376462E70A2FA32B0B3AFA70F63DCA07">Preziuso, Francesca</mods:namePart>
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<mods:affiliation id="E2B60B76AF83DFD92C44EE7A243B19F1">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="874E794DA106B8DA35E44ACD3FA193C0">Taddeo, Vito Alessandro</mods:namePart>
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<mods:affiliation id="7E989AC79266A6DDB2526E1FA07C8DA5">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="6F938CC83536A723E83FDE93337CAC8B">Genovese, Salvatore</mods:namePart>
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<mods:affiliation id="E2E1A258104D582E0BDDA26C4D2E6E22">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:title id="111C13CE5EFE5DAD296DFD83DA7737F9">Phytochemistry</mods:title>
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<mods:date id="B1A9DA6F4641280EF36691653CBB8077">2018</mods:date>
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<mods:number id="512B66EA39ECEF3AD7FBAA620EBBAED1">153</mods:number>
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<mods:identifier id="4109E80499336DA68C36C79C40628B59" type="ISSN">1873-3700</mods:identifier>
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<treatment id="0385EF62FF97FF84FC91D26AFBF136F0" LSID="urn:lsid:plazi:treatment:0385EF62FF97FF84FC91D26AFBF136F0" httpUri="http://treatment.plazi.org/id/0385EF62FF97FF84FC91D26AFBF136F0" lastPageNumber="4" pageId="3" pageNumber="4">
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<subSubSection id="C3360DFFFF97FF84FC91D26AFB8D347E" box="[818,1101,1331,1350]" pageId="3" pageNumber="4" type="nomenclature">
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<paragraph id="8B935E74FF97FF84FC91D26AFB8D347E" blockId="3.[818,1101,1331,1350]" box="[818,1101,1331,1350]" pageId="3" pageNumber="4">
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<heading id="D0DBE918FF97FF84FC91D26AFB8D347E" bold="true" box="[818,1101,1331,1350]" fontSize="36" level="1" pageId="3" pageNumber="4" reason="1">
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<emphasis id="B9588266FF97FF84FC91D26AFB8D347E" bold="true" box="[818,1101,1331,1350]" italics="true" pageId="3" pageNumber="4">
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5.3.1.
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<taxonomicName id="4C2C25F7FF97FF84FCD1D26AFB8D347E" ID-CoL="4C9K7" authority="C. A. Mey" authorityName="C. A. Mey" box="[882,1101,1331,1350]" class="Magnoliopsida" family="Araliaceae" genus="Panax" kingdom="Plantae" order="Apiales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="ginseng">Panax ginseng C.A. Mey</taxonomicName>
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<paragraph id="8B935E74FF97FF84FCF0D216FBF136F0" blockId="3.[818,1487,1359,1992]" pageId="3" pageNumber="4">
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Polysaccharides from
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<taxonomicName id="4C2C25F7FF97FF84FB82D216FBB9345A" box="[1057,1145,1359,1378]" class="Magnoliopsida" family="Araliaceae" genus="Panax" kingdom="Plantae" order="Apiales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="ginseng">
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<emphasis id="B9588266FF97FF84FB82D216FBB9345A" bold="true" box="[1057,1145,1359,1378]" italics="true" pageId="3" pageNumber="4">P. ginseng</emphasis>
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, among the most widely known and used medicinal plant, have been already shown promising anti-proliferative effects against several cancer cell lines (
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<bibRefCitation id="EFBD2385FF97FF84FAA9D2DEFAAA34A2" author="Sun, X. Y." box="[1290,1386,1415,1434]" pageId="3" pageNumber="4" pagination="490 - 499" refId="ref13109" refString="Sun, X. Y., 2011. Structure and biological activities of the polysaccharides from leaves, roots, and fruits of Panax ginseng C. A. Meyer: an overview. Carbohydr. Polym. 85, 490 - 499." type="journal article" year="2011">Sun, 2011</bibRefCitation>
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). In 2017, Liao and coworkers synthesized a Se-P deriving from an aqueous extract of ginseng roots obtaining a Se content of
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/g. The growth inhibitory effects of this Se-P were first investigated
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<emphasis id="B9588266FF97FF84FAAFD283FA8B34D5" bold="true" box="[1292,1355,1498,1517]" italics="true" pageId="3" pageNumber="4">in vitro</emphasis>
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using the HL-60 (human leukemia) cell line. Cells were incubated for 24–72 h with increasing concentrations of the Se-P in the range 25–400 μg/mL. The best results have been obtained after 48 h with applied doses of 50 μg/ mL, 100 μg/mL, and 200 μg/mL leading to a reduction of surviving cells in the range 34.2%–53.6%. These concentration levels were then selected to perform further tests. The next parameter evaluated was the release of LDH, well established to be a signal of apoptotic induction and progress. The administration of Se-P provided a dose-dependent increase of LDH release. HL-60 cells were also morphologically examined. The group treated with the Se-P at 200 μg/mL was characterized by cell shrinkage, condensed nuclei, and fragmented cell membranes. Furthermore, the induction of apoptosis occurred at a mithochondrial level with changes in the
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<emphasis id="B9588266FF97FF84FB77D01CFAC03660" bold="true" box="[1236,1280,1861,1880]" italics="true" pageId="3" pageNumber="4">trans</emphasis>
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-membrane potential, activation of pro-caspase 9, in turn leading to cleavage of caspase 9, caspase 3, and PARP, to a dose-dependent increase of the expression of the pro-apoptotic protein Bax and in the mean time a decrease of the anti-apoptotic factor Bcl-2.
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</paragraph>
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</subSubSection>
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</treatment>
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