140 lines
15 KiB
XML
140 lines
15 KiB
XML
<document id="1065663BF7DC68B3760A2F5CA10DD9C1" ID-DOI="10.1016/j.phytochem.2018.05.008" ID-ISSN="1873-3700" ID-Zenodo-Dep="10483984" IM.bibliography_approvedBy="felipe" IM.illustrations_approvedBy="felipe" IM.materialsCitations_approvedBy="juliana" IM.metadata_approvedBy="juliana" IM.taxonomicNames_approvedBy="juliana" IM.treatments_approvedBy="juliana" checkinTime="1704938445945" checkinUser="felipe" docAuthor="Fiorito, Serena, Epifano, Francesco, Preziuso, Francesca, Taddeo, Vito Alessandro & Genovese, Salvatore" docDate="2018" docId="0385EF62FF91FF81FC91D2AFFDA43268" docLanguage="en" docName="Phytochemistry.153.1-10.pdf" docOrigin="Phytochemistry 153" docSource="http://dx.doi.org/10.1016/j.phytochem.2018.05.008" docStyle="DocumentStyle:9E596C34F4E94307D29315B03ACE1007.6:Phytochemistry.2014-2019.journal_article" docStyleId="9E596C34F4E94307D29315B03ACE1007" docStyleName="Phytochemistry.2014-2019.journal_article" docStyleVersion="6" docTitle="Schisandra chinensis Baill" docType="treatment" docVersion="1" lastPageNumber="6" masterDocId="FFBC971AFF94FF87FFA3D759FFC03138" masterDocTitle="Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties" masterLastPageNumber="10" masterPageNumber="1" pageNumber="6" updateTime="1705322845058" updateUser="juliana">
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<mods:titleInfo id="3F29F21DFD9D242065F0FFEF6F2929E5">
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<mods:title id="3BE841101C353A6F06465B38C9674264">Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties</mods:title>
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<mods:name id="9FEFBE19C6C3D5B1955B45FAF011E528" type="personal">
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<mods:namePart id="AC8FBEDB8E02EFA36D25D10924398C1F">Fiorito, Serena</mods:namePart>
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<mods:affiliation id="A7DE4DB2AECD0D3B49D2CF883BF75ED3">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy & Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia, Italy</mods:affiliation>
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<mods:namePart id="249DBADCCEC7F36D22E6199511413E1A">Epifano, Francesco</mods:namePart>
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<mods:affiliation id="BCBC66F563F8F92C9B664C7FEBDE32AF">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:nameIdentifier id="25C5D982462A3ED7DB20C4BD81A15264" type="email">fepifano@unich.it</mods:nameIdentifier>
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<mods:namePart id="C64CAB481D2F0013D899BF77A5D3E48B">Preziuso, Francesca</mods:namePart>
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<mods:affiliation id="3EC8823FAC4A035E40B5AC88BC5849FF">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="AEC4917321B86602C352069838944BA6">Taddeo, Vito Alessandro</mods:namePart>
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<mods:affiliation id="EF24A16F6D4007FCFBCE293B1B161F11">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="16357F19889D6BFDE2EBD1D2AB1BD927">Genovese, Salvatore</mods:namePart>
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<mods:affiliation id="2D96134EA1C7DCF0182A38FBB5C1E897">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:typeOfResource id="13642652B314F2ACBDE35222448D82FA">text</mods:typeOfResource>
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<mods:title id="BFD58A942ED5DCF118F633C9507C86B8">Phytochemistry</mods:title>
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<mods:part id="F328794D010833C3078CA56592A72BCD">
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<mods:date id="7B0F9B7FD1BC583016CC6CD3EE2934EF">2018</mods:date>
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<mods:number id="49190AE04206B918B40FC2F34102A6D0">2018-09-30</mods:number>
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<mods:number id="3ACA24E921EED90E8E323A70A519BB08">153</mods:number>
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<mods:url id="00F32AB834D430A8BA81BC0972285EFB">http://dx.doi.org/10.1016/j.phytochem.2018.05.008</mods:url>
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<mods:classification id="00F97D87631EFF060648324F7BD5BA42">journal article</mods:classification>
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<mods:identifier id="4B013B230E9CC5C79BDC982DDAD68D0E" type="DOI">10.1016/j.phytochem.2018.05.008</mods:identifier>
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<mods:identifier id="6F8A91E4ABF12769C1243D68874981DF" type="ISSN">1873-3700</mods:identifier>
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<mods:identifier id="E3058E1F100FCED09EBEDD7B54D24182" type="Zenodo-Dep">10483984</mods:identifier>
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<treatment id="0385EF62FF91FF81FC91D2AFFDA43268" LSID="urn:lsid:plazi:treatment:0385EF62FF91FF81FC91D2AFFDA43268" httpUri="http://treatment.plazi.org/id/0385EF62FF91FF81FC91D2AFFDA43268" lastPageId="6" lastPageNumber="6" pageId="5" pageNumber="6">
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<subSubSection id="C3360DFFFF91FF82FC91D2AFFB763731" box="[818,1206,1526,1545]" pageId="5" pageNumber="6" type="nomenclature">
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<paragraph id="8B935E74FF91FF82FC91D2AFFB763731" blockId="5.[818,1206,1526,1545]" box="[818,1206,1526,1545]" pageId="5" pageNumber="6">
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<heading id="D0DBE918FF91FF82FC91D2AFFB763731" bold="true" box="[818,1206,1526,1545]" fontSize="36" level="1" pageId="5" pageNumber="6" reason="1">
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<emphasis id="B9588266FF91FF82FC91D2AFFB763731" bold="true" box="[818,1206,1526,1545]" italics="true" pageId="5" pageNumber="6">
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5.13.1.
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<taxonomicName id="4C2C25F7FF91FF82FCDED2AFFB763731" ID-CoL="4V8HZ" authority="(Turcz.) Baill" authorityName="Baill" baseAuthorityName="Turcz." box="[893,1206,1526,1545]" class="Magnoliopsida" family="Schisandraceae" genus="Schisandra" kingdom="Plantae" order="Austrobaileyales" pageId="5" pageNumber="6" phylum="Tracheophyta" rank="species" species="chinensis">Schisandra chinensis (Turcz.) Baill</taxonomicName>
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</emphasis>
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</heading>
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</paragraph>
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</subSubSection>
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<subSubSection id="C3360DFFFF91FF81FCF0D14BFDA43268" lastPageId="6" lastPageNumber="7" pageId="5" pageNumber="6" type="description">
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<paragraph id="8B935E74FF91FF81FCF0D14BFDA43268" blockId="5.[818,1488,1554,1992]" lastBlockId="6.[100,771,159,848]" lastPageId="6" lastPageNumber="7" pageId="5" pageNumber="6">
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<taxonomicName id="4C2C25F7FF91FF82FCF0D14BFBFC371D" authority="(Wu Wei Zi)" baseAuthorityName="Wu Wei Zi" box="[851,1084,1554,1573]" class="Magnoliopsida" family="Schisandraceae" genus="Schisandra" kingdom="Plantae" order="Austrobaileyales" pageId="5" pageNumber="6" phylum="Tracheophyta" rank="species" species="chinensis">
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<emphasis id="B9588266FF91FF82FCF0D14BFC7B371D" bold="true" box="[851,955,1554,1573]" italics="true" pageId="5" pageNumber="6">S. chinensis</emphasis>
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(Wu Wei Zi)
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</taxonomicName>
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is a plant native of
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<collectingCountry id="F33B1EE4FF91FF82FAA6D14BFA81371D" box="[1285,1345,1554,1573]" name="Russia" pageId="5" pageNumber="6">Russia</collectingCountry>
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but nowadays widespread in several Asian countries. Polysaccharides from fruits (called magnolia berries) of this species have been shown to exert antitumor, anti-oxidant, and immunomodulatory effects (
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<bibRefCitation id="EFBD2385FF91FF82FA92D13FFA013741" author="Qu, H. M. & Liu, S. J. & Zhang, C. Y." box="[1329,1473,1638,1657]" pageId="5" pageNumber="6" pagination="52 - 56" refId="ref12850" refString="Qu, H. M., Liu, S. J., Zhang, C. Y., 2014. Antitumor and antiangiogenic activity of Schisandra chinensis polysaccharide in a renal cell carcinoma model. Int. J. Biol. Macromol. 66, 52 - 56." type="journal article" year="2014">Qu et al., 2014</bibRefCitation>
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). In 2015 Yue and coworkers synthesized a library of 9 Se-Ps using the carbohydrate fraction from the whole plant with yields in the range 32.6%–54.9% and Se content varying from
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<quantity id="4CD4F391FF91FF82FB73D1E0FAD137F4" box="[1232,1297,1721,1740]" metricMagnitude="-6" metricUnit="kg" metricValue="3.8" pageId="5" pageNumber="6" unit="mg" value="3.8">3.8 mg</quantity>
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/kg to
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<quantity id="4CD4F391FF91FF82FAF2D1E0FA6B37F4" box="[1361,1451,1721,1740]" metricMagnitude="-5" metricUnit="kg" metricValue="1.035" pageId="5" pageNumber="6" unit="mg" value="10.35">10.35 mg</quantity>
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/kg. All samples were preliminarily screened for their anti-oxidant activity using the DPPH, hydroxyl radical, and ABTS scavenging capacities applying concentration from
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<quantity id="4CD4F391FF91FF82FBE7D054FB673618" box="[1092,1191,1805,1824]" metricMagnitude="-8" metricUnit="kg" metricValue="6.26" pageId="5" pageNumber="6" unit="mg" value="0.0626">0.0626 mg</quantity>
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/mL to
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<quantity id="4CD4F391FF91FF82FB4ED054FADC3618" box="[1261,1308,1805,1824]" metricMagnitude="-6" metricUnit="kg" metricValue="1.0" pageId="5" pageNumber="6" unit="mg" value="1.0">1 mg</quantity>
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/mL.
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<emphasis id="B9588266FF91FF82FAEDD054FA4E3618" bold="true" box="[1358,1422,1805,1824]" italics="true" pageId="5" pageNumber="6">In vitro</emphasis>
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assays showed a dose-dependent scavenging activity. The Se-P characterized by a content in Se of
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<quantity id="4CD4F391FF91FF82FC5DD01CFB803660" box="[1022,1088,1861,1880]" metricMagnitude="-6" metricUnit="kg" metricValue="5.4" pageId="5" pageNumber="6" unit="mg" value="5.4">5.4 mg</quantity>
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/g displaying the best performance. In the case of
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<taxonomicName id="4C2C25F7FF91FF82FCD9D038FC22364C" box="[890,994,1889,1908]" class="Magnoliopsida" family="Schisandraceae" genus="Schisandra" kingdom="Plantae" order="Austrobaileyales" pageId="5" pageNumber="6" phylum="Tracheophyta" rank="species" species="chinensis">
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<emphasis id="B9588266FF91FF82FCD9D038FC22364C" bold="true" box="[890,994,1889,1908]" italics="true" pageId="5" pageNumber="6">S. chinensis</emphasis>
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</taxonomicName>
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to some extent the native polysaccharide exhibited an anti-oxidant effect comparable or even higher respect to some Se-Ps. The most efficient Se-P in
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<emphasis id="B9588266FF91FF82FB80D0C0FBA13694" bold="true" box="[1059,1121,1945,1964]" italics="true" pageId="5" pageNumber="6">in vitro</emphasis>
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assays was then selected to accomplish further studies consisting in the evaluation of the inhibitory capacities of protein glycation, determination of activities of CAT and SOD, and content of MDA. White Roman chickens vaccinated with ND vaccine were used to this purpose and injected i.m. for 3 days with the Se-P at a dose of
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<quantity id="4CD4F391FF92FF81FF0FD7AAFF1D303E" box="[172,221,243,262]" metricMagnitude="-6" metricUnit="kg" metricValue="2.0" pageId="6" pageNumber="7" unit="mg" value="2.0">2 mg</quantity>
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/kg. Measurements were accomplished every 1 week along 4 weeks of duration of the experiment. Only slight differences were noted in animals treated with the native polymer and the Se-P for what concerns the anti-glycation capacity. On the contrary in the case of CAT, SOD, and MDA the Se-P recorded much higher values. The same research group in 2017 investigated the effects of the same Se-P used in 2015 as an anti-oxidant agent and got insights into the mechanism of action in chicken embryo hepatocytes applying doses of 1 μg/mL, 10 μg/mL, and 100 μg/mL. H
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O
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<subScript id="17A85C31FF92FF81FE3FD682FE6530D0" attach="left" box="[412,421,475,488]" fontSize="5" pageId="6" pageNumber="7">2</subScript>
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and
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<emphasis id="B9588266FF92FF81FE7FD68BFE2B30DD" bold="true" box="[476,491,466,485]" italics="true" pageId="6" pageNumber="7">N</emphasis>
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-acetylcysteine were used as controls. The administration of the Se-P had no effects on cell viability, while decreasing the extent of apoptosis in cells treated with H
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<subScript id="17A85C31FF92FF81FD65D54BFD0F3327" attach="both" box="[710,719,530,543]" fontSize="5" pageId="6" pageNumber="7">2</subScript>
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O
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<subScript id="17A85C31FF92FF81FD7DD54BFD273327" attach="left" box="[734,743,530,543]" fontSize="5" pageId="6" pageNumber="7">2</subScript>
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of about 25%. The production of ROS induced by the same chemical was also diminished of about 35% and to values comparable to those recorded for
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<emphasis id="B9588266FF92FF81FF6ED507FF233349" bold="true" box="[205,227,606,625]" italics="true" pageId="6" pageNumber="7">N-</emphasis>
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acetylcysteine. A massive increase in the activity of CAT, SOD, and GSH, and a decrease in MDA content were also observed. Trying to rationalize the mechanism of action underlying the recorded effects, Yue and coworkers assessed also that the Se-P had the capacity to down-regulate the genomic expression of
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<emphasis id="B9588266FF92FF81FD81D594FDEC33D8" bold="true" box="[546,556,717,736]" italics="true" pageId="6" pageNumber="7">p</emphasis>
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-JNK
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<subScript id="17A85C31FF92FF81FDF9D58FFDA333DB" attach="left" box="[602,611,726,739]" fontSize="5" pageId="6" pageNumber="7">1</subScript>
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,
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<emphasis id="B9588266FF92FF81FDD7D594FDBE33D8" bold="true" box="[628,638,717,736]" italics="true" pageId="6" pageNumber="7">p</emphasis>
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-ERK
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<subScript id="17A85C31FF92FF81FD0ED58FFD0733DB" attach="left" box="[685,711,726,739]" fontSize="5" pageId="6" pageNumber="7">1/2</subScript>
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, P38, Box, caspase 3, and cytochrome
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<emphasis id="B9588266FF92FF81FE00D5B0FE6C33C4" bold="true" box="[419,428,745,764]" italics="true" pageId="6" pageNumber="7">c</emphasis>
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while up-regulating Bcl-2. Thus, it may be hypothesized that the strong effect of Se-Ps against cell damages induced by H
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<subScript id="17A85C31FF92FF81FF44D470FF30320E" attach="both" box="[231,240,809,822]" fontSize="5" pageId="6" pageNumber="7">2</subScript>
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O
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<subScript id="17A85C31FF92FF81FEA3D470FEC9320E" attach="left" box="[256,265,809,822]" fontSize="5" pageId="6" pageNumber="7">2</subScript>
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is due to a positive regulatory effect on MAPK and mithochondrial-dependent apoptotic signal pathways.
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</paragraph>
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</subSubSection>
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</treatment>
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</document> |