149 lines
13 KiB
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149 lines
13 KiB
XML
<document id="282AD4D6562C1B6B030C8A022B52A7C2" ID-CLB-Dataset="264564" ID-DOI="10.1016/j.phytochem.2019.112222" ID-GBIF-Dataset="4a860314-bd9c-4c55-9f10-852e402b1aef" ID-ISSN="1873-3700" ID-Zenodo-Dep="8292998" IM.illustrations_approvedBy="carolina" IM.materialsCitations_approvedBy="felipe" IM.metadata_approvedBy="felipe" IM.taxonomicNames_approvedBy="carolina" IM.treatments_approvedBy="carolina" checkinTime="1693250931468" checkinUser="felipe" docAuthor="Micucci, M., Bolchi, C., Budriesi, R., Cevenini, M., Maroni, L., Capozza, S., Chiarini, A., Pallavicini, M. & Angeletti, A." docDate="2020" docId="03E4D873FFFDDC5CFC8DB462BF631C4E" docLanguage="en" docName="Phytochemistry.170.112222.pdf" docOrigin="Phytochemistry (112222) 170" docSource="http://dx.doi.org/10.1016/j.phytochem.2019.112222" docStyle="DocumentStyle:F36D69FC8B198FBE91029DF9C24697D3.5:Phytochemistry.2020-.journal_article" docStyleId="F36D69FC8B198FBE91029DF9C24697D3" docStyleName="Phytochemistry.2020-.journal_article" docStyleVersion="5" docTitle="Zingiber cinale Roscoe" docType="treatment" docVersion="4" lastPageNumber="11" masterDocId="FFDDA00BFFF7DC57FFBFB12FBD10184C" masterDocTitle="Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents" masterLastPageNumber="19" masterPageNumber="1" pageNumber="11" updateTime="1693417694953" updateUser="ExternalLinkService">
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<mods:title id="727FFE8A1CBD77CB63210FAB621CB170">Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents</mods:title>
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<mods:namePart id="715EB6A0F618B0C824CE438D4A8B2B47">Micucci, M.</mods:namePart>
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<mods:affiliation id="7E07D5D50BAEE3333D028D28B28E946E">∗ & Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro, 6, 40126, Italy</mods:affiliation>
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<mods:namePart id="16DD5CC8E3522AB38667D1C4FF354736">Budriesi, R.</mods:namePart>
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<mods:namePart id="22549699FDD0ABB85D3476DC08657E1E">Maroni, L.</mods:namePart>
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<mods:namePart id="DD2E4B633FCC57E4DA5EACE46D0D3EC7">Capozza, S.</mods:namePart>
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<mods:namePart id="C61274A6795048A46B472A02C52CC9F8">Chiarini, A.</mods:namePart>
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<mods:title id="2EFBB9BEF9C41DADAFF63FE97F8EF02A">Phytochemistry</mods:title>
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<mods:date id="FF09F20C376D7BAEF4943409C555774C">2020</mods:date>
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<mods:number id="8A74054C764AC4BA9B76632CF87BA419">2020-02-29</mods:number>
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<treatment id="03E4D873FFFDDC5CFC8DB462BF631C4E" ID-DOI="http://doi.org/10.5281/zenodo.8302652" ID-Zenodo-Dep="8302652" LSID="urn:lsid:plazi:treatment:03E4D873FFFDDC5CFC8DB462BF631C4E" httpUri="http://treatment.plazi.org/id/03E4D873FFFDDC5CFC8DB462BF631C4E" lastPageId="11" lastPageNumber="11" pageId="10" pageNumber="11">
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<subSubSection id="C3573AEEFFFDDC5DFC8DB462B9401D2C" box="[818,1104,1356,1376]" pageId="10" pageNumber="11" type="nomenclature">
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<paragraph id="8BF26965FFFDDC5DFC8DB462B9401D2C" blockId="10.[818,1104,1356,1376]" box="[818,1104,1356,1376]" pageId="10" pageNumber="11">
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<heading id="D0BADE09FFFDDC5DFC8DB462B9401D2C" box="[818,1104,1356,1376]" fontSize="8" level="3" pageId="10" pageNumber="11" reason="8">
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<emphasis id="B939B577FFFDDC5DFC8DB462BED51D2C" bold="true" box="[818,965,1357,1376]" italics="true" pageId="10" pageNumber="11">
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2.13.
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<taxonomicName id="4C4D12E6FFFDDC5DFCD3B462B9401D2C" ID-CoL="8W4TG" ID-ENA="4650" authority="Roscoe" authorityName="Roscoe" box="[876,1104,1356,1376]" class="Liliopsida" family="Zingiberaceae" genus="Zingiber" kingdom="Plantae" order="Zingiberales" pageId="10" pageNumber="11" phylum="Tracheophyta" rank="genus">
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Zingiber o ffi
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<emphasis id="B939B577FFFDDC5DFC67B462B9401D2C" bold="true" box="[984,1104,1357,1376]" italics="true" pageId="10" pageNumber="11">cinale Roscoe</emphasis>
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</taxonomicName>
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</emphasis>
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</emphasis>
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</heading>
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</paragraph>
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<subSubSection id="C3573AEEFFFDDC5CFCECB4ABBF631C4E" lastPageId="11" lastPageNumber="12" pageId="10" pageNumber="11" type="description">
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<paragraph id="8BF26965FFFDDC5DFCECB4ABB9611E4B" blockId="10.[818,1487,1412,1989]" pageId="10" pageNumber="11">
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<taxonomicName id="4C4D12E6FFFDDC5DFCECB4ABB9591DDB" authority="Roscoe" authorityName="Roscoe" box="[851,1097,1412,1431]" class="Liliopsida" family="Zingiberaceae" genus="Zingiber" kingdom="Plantae" order="Zingiberales" pageId="10" pageNumber="11" phylum="Tracheophyta" rank="genus">
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<emphasis id="B939B577FFFDDC5DFCECB4ABBED51DDB" box="[851,965,1412,1431]" italics="true" pageId="10" pageNumber="11">
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<emphasis id="B939B577FFFDDC5DFCECB4ABBEA21DDB" bold="true" box="[851,946,1412,1431]" italics="true" pageId="10" pageNumber="11">Zingiber o</emphasis>
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ffi
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</emphasis>
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<emphasis id="B939B577FFFDDC5DFC7AB4ABBEE91DDB" bold="true" box="[965,1017,1412,1431]" italics="true" pageId="10" pageNumber="11">cinale</emphasis>
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Roscoe
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</taxonomicName>
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rhizome is widely used in Ayurvedic medicine, as a treatment for gastrointestinal and cardiovascular ailments. The rhizome contains phenolic compounds and non-volatile pungent active principles including gingerols, paradols, shogaols and gingerones (Semwal et al., 2015).
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</paragraph>
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<paragraph id="8BF26965FFFDDC5DFCECB73FB9BB1EAA" blockId="10.[818,1487,1412,1989]" pageId="10" pageNumber="11">
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A water extract from
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<emphasis id="B939B577FFFDDC5DFBA1B73FB9981E6F" box="[1054,1160,1552,1571]" italics="true" pageId="10" pageNumber="11">
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<emphasis id="B939B577FFFDDC5DFBA1B73FB9511E6F" bold="true" box="[1054,1089,1552,1571]" italics="true" pageId="10" pageNumber="11">Z. o</emphasis>
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ffi
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<taxonomicName id="4C4D12E6FFFDDC5DFBEBB73FB9981E6F" box="[1108,1160,1552,1571]" class="Liliopsida" family="Zingiberaceae" genus="Zingiber" higherTaxonomySource="CoL" kingdom="Plantae" order="Zingiberales" pageId="10" pageNumber="11" phylum="Tracheophyta" rank="species" species="cinale">
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<emphasis id="B939B577FFFDDC5DFBEBB73FB9981E6F" bold="true" box="[1108,1160,1552,1571]" italics="true" pageId="10" pageNumber="11">cinale</emphasis>
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</taxonomicName>
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was shown to inhibit ACE activity in a concentration-dependent manner (Akinyemi et al., 2014). This effect occurs also
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<emphasis id="B939B577FFFDDC5DFC54B767B93C1E17" bold="true" box="[1003,1068,1608,1627]" italics="true" pageId="10" pageNumber="11">in vivo</emphasis>
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, in rats fed with a high cholesterol diet (Akinyemi et al., 2014). The same extract reduces mean arterial BP in L-NAME induced hypertensive rats. Butanol and ethyl acetate fractions seem to be more active than the water fraction (Manosroi et al., 2013). Efficacy of ginger supplementation on BP in clinical trials has been recently reviewed (Hasani et al., 2019).
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</paragraph>
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<paragraph id="8BF26965FFFDDC5CFCECB7C0BF631C4E" blockId="10.[818,1487,1412,1989]" lastBlockId="11.[100,770,756,1026]" lastPageId="11" lastPageNumber="12" pageId="10" pageNumber="11">
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<emphasis id="B939B577FFFDDC5DFCECB7C0BE841F4E" bold="true" box="[851,916,1775,1794]" italics="true" pageId="10" pageNumber="11">In vitro</emphasis>
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<materialsCitation id="3B256338FFFDDC5CFC23B7C0BF7F1C4E" collectionCode="NO" lastPageId="11" lastPageNumber="12" pageId="10" pageNumber="11" specimenCount="1">
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experiments on guinea pig isolated tissues showed that the decoction of ginger possesses weak negative inotropic and chronotropic intrinsic activities, along with a significant intrinsic relaxant activity on smooth muscle with a greater potency on ileum than on aorta. The study on the main pure components supports the relationship between 6- and 8-gingerol and 6-shogaol and these effects. These results are in agreement with the activity of calcium channel modulators, which influence more strongly the not vascular muscles than vascular one (Leoni et al., 2017). Previous researches had evidenced, for 6-, 8- and 10- gingerol and, to a minor extent, also for 6-shogaol (
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<figureCitation id="137675E0FFFCDC5CFDEAB23FBF871B6F" box="[597,663,784,803]" captionStart="Fig" captionStartId="11.[566,596,693,710]" captionTargetBox="[227,1360,152,670]" captionTargetPageId="11" captionText="Fig. 13. Antihypertensive principles of Z. officinale L." figureDoi="http://doi.org/10.5281/zenodo.8293022" httpUri="https://zenodo.org/record/8293022/files/figure.png" pageId="11" pageNumber="12">Fig. 13</figureCitation>
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), a vasodilator effect through a combination of
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<collectionCode id="ED5CF1A0FFFCDC5CFE62B203BCEC1B73" box="[477,508,812,831]" country="USA" lsid="urn:lsid:biocol.org:col:15617" name="Tulane University Herbarium" pageId="11" pageNumber="12" type="Herbarium">NO</collectionCode>
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releasing and calcium antagonist mechanism (Ghayur et al., 2005). More recently, 6-gingerol has been shown to attenuate the increased level of blood glucose and to improve cardiac hemodynamics in diabetic rats (El-Bassossy et al., 2016) and it has been identified as a novel angiotensin II
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<typeStatus id="54F6D7C7FFFCDC5CFD1DB2B4BFDB1BE2" box="[674,715,923,942]" pageId="11" pageNumber="12">type</typeStatus>
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1 receptor antagonist (Liu et al., 2013). Inhibition of TGF-β- stimulated biglycan synthesis by 6-gingerol suggests the potential role of ginger in the prevention of atherosclerosis (Kamato et al., 2013)
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</materialsCitation>
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.
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</paragraph>
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</subSubSection>
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</treatment>
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