164 lines
17 KiB
XML
164 lines
17 KiB
XML
<document id="B671B95E4C0E098FE5AB3F45A63F5BFE" ID-CLB-Dataset="264564" ID-DOI="10.1016/j.phytochem.2019.112222" ID-GBIF-Dataset="4a860314-bd9c-4c55-9f10-852e402b1aef" ID-ISSN="1873-3700" ID-Zenodo-Dep="8292998" IM.illustrations_approvedBy="carolina" IM.materialsCitations_approvedBy="felipe" IM.metadata_approvedBy="felipe" IM.taxonomicNames_approvedBy="carolina" IM.treatments_approvedBy="carolina" checkinTime="1693250931468" checkinUser="felipe" docAuthor="Micucci, M., Bolchi, C., Budriesi, R., Cevenini, M., Maroni, L., Capozza, S., Chiarini, A., Pallavicini, M. & Angeletti, A." docDate="2020" docId="03E4D873FFF1DC50FC8DB233BDB21985" docLanguage="en" docName="Phytochemistry.170.112222.pdf" docOrigin="Phytochemistry (112222) 170" docSource="http://dx.doi.org/10.1016/j.phytochem.2019.112222" docStyle="DocumentStyle:F36D69FC8B198FBE91029DF9C24697D3.5:Phytochemistry.2020-.journal_article" docStyleId="F36D69FC8B198FBE91029DF9C24697D3" docStyleName="Phytochemistry.2020-.journal_article" docStyleVersion="5" docTitle="Alpinia zerumbet B. L. Burtt & R. M. Sm" docType="treatment" docVersion="4" lastPageNumber="8" masterDocId="FFDDA00BFFF7DC57FFBFB12FBD10184C" masterDocTitle="Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents" masterLastPageNumber="19" masterPageNumber="1" pageNumber="7" updateTime="1693417694953" updateUser="ExternalLinkService">
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<mods:title id="4C8F2B5718060826F738AD83B4412A85">Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents</mods:title>
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<mods:namePart id="5255E02FA9BE6DA0F5114CB26D7348F0">Micucci, M.</mods:namePart>
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<mods:affiliation id="1DDF966F162CA0511C99EFFE349F8CC2">∗ & Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro, 6, 40126, Italy</mods:affiliation>
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<mods:namePart id="5CE56A805893FB71193448CC90C2B5AC">Bolchi, C.</mods:namePart>
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<mods:namePart id="A2A9DE9ABEEBA480C4F7B06D9C96946B">Budriesi, R.</mods:namePart>
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<mods:namePart id="102493AED03076E3E8155859E8EE2B55">Cevenini, M.</mods:namePart>
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<mods:namePart id="08D4654404FEE8F7EEE36A8730A1C5A0">Maroni, L.</mods:namePart>
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<mods:namePart id="1B9D9DBD2039BBE53EDB07444A5B99CD">Capozza, S.</mods:namePart>
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<mods:namePart id="04ABCF86C8C55865349E380D6B6FE912">Chiarini, A.</mods:namePart>
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<mods:namePart id="4853D358E439588B4AF5576A3BA71BC4">Pallavicini, M.</mods:namePart>
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<treatment id="03E4D873FFF1DC50FC8DB233BDB21985" ID-DOI="http://doi.org/10.5281/zenodo.8302640" ID-Zenodo-Dep="8302640" LSID="urn:lsid:plazi:treatment:03E4D873FFF1DC50FC8DB233BDB21985" httpUri="http://treatment.plazi.org/id/03E4D873FFF1DC50FC8DB233BDB21985" lastPageId="7" lastPageNumber="8" pageId="6" pageNumber="7">
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<subSubSection id="C3573AEEFFF1DC51FC8DB233B9E71B63" box="[818,1271,796,815]" pageId="6" pageNumber="7" type="nomenclature">
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<paragraph id="8BF26965FFF1DC51FC8DB233B9E71B63" blockId="6.[818,1271,796,815]" box="[818,1271,796,815]" pageId="6" pageNumber="7">
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<heading id="D0BADE09FFF1DC51FC8DB233B9E71B63" bold="true" box="[818,1271,796,815]" fontSize="36" level="1" pageId="6" pageNumber="7" reason="1">
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2.7.
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<taxonomicName id="4C4D12E6FFF1DC51FCDFB233B9E71B63" ID-CoL="C6ZV" ID-ENA="97723" authority="(Pers.) B. L. Burtt & R. M. Sm" authorityName="B. L. Burtt & R. M. Sm" baseAuthorityName="Pers." box="[864,1271,796,815]" class="Liliopsida" family="Zingiberaceae" genus="Alpinia" kingdom="Plantae" order="Zingiberales" pageId="6" pageNumber="7" phylum="Tracheophyta" rank="species" species="zerumbet">Alpinia zerumbet (Pers.) B.L.Burtt & R.M.Sm</taxonomicName>
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</emphasis>
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<subSubSection id="C3573AEEFFF1DC50FCECB27BBDB21985" lastPageId="7" lastPageNumber="8" pageId="6" pageNumber="7" type="description">
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<paragraph id="8BF26965FFF1DC51FCECB27BBE611BF6" blockId="6.[818,1488,852,1624]" pageId="6" pageNumber="7">
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<taxonomicName id="4C4D12E6FFF1DC51FCECB27BB9E21B2B" authority="(Pers.) B. L. Burtt & R. M. Sm" authorityName="B. L. Burtt & R. M. Sm" baseAuthorityName="Pers." box="[851,1266,852,871]" class="Liliopsida" family="Zingiberaceae" genus="Alpinia" kingdom="Plantae" order="Zingiberales" pageId="6" pageNumber="7" phylum="Tracheophyta" rank="species" species="zerumbet">
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<emphasis id="B939B577FFF1DC51FCECB27BBEFA1B2B" bold="true" box="[851,1002,852,871]" italics="true" pageId="6" pageNumber="7">Alpinia zerumbet</emphasis>
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(Pers.) B.L.Burtt & R.M.Sm
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</taxonomicName>
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is a tropical plant that originates in South America and Asia, whose leaves are used in folk medicine for the treatment of hypertension and gastrointestinal ailments.
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</paragraph>
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<paragraph id="8BF26965FFF1DC51FCECB2ECB9A21C66" blockId="6.[818,1488,852,1624]" pageId="6" pageNumber="7">Extracts from leaves mainly contain flavonoids, such as (+)-catechin, (−)-epicatechin, rutin, quercetin, kaempferol and its glucosides, and kava pyrones, including dihydro-5,6-dehydrokawain and 5,6-dehydrokawain (Mpalantinos et al., 1998).</paragraph>
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<paragraph id="8BF26965FFF1DC51FCECB51CB9EF1DD8" blockId="6.[818,1488,852,1624]" pageId="6" pageNumber="7">
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<taxonomicName id="4C4D12E6FFF1DC51FCECB51CBEAF1C0A" box="[851,959,1075,1094]" class="Liliopsida" family="Zingiberaceae" genus="Alpinia" kingdom="Plantae" order="Zingiberales" pageId="6" pageNumber="7" phylum="Tracheophyta" rank="species" species="zerumbet">
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<emphasis id="B939B577FFF1DC51FCECB51CBEAF1C0A" bold="true" box="[851,959,1075,1094]" italics="true" pageId="6" pageNumber="7">A. zerumbet</emphasis>
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</taxonomicName>
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leaves extract produces vasodilation in the mesenteric vascular bed, which was reverted by L-NAME and [1,2,3]oxadiazolo [4,4-a]quinoxalin-1-one (ODQ), suggesting the involvement of endothelium. This effect is due, at least in part, to activation of NO synthase and soluble guanylyl cyclase (GC), and to B2 bradykinin receptors antagonism (de Moura et al., 2005; Galleano et al., 2010).
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<emphasis id="B939B577FFF1DC51FAD2B591B8BB1C9D" bold="true" box="[1389,1451,1214,1233]" italics="true" pageId="6" pageNumber="7">In vivo</emphasis>
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experiments showed also the involvement of endothelium-derived relaxing factors in the hypotensive action of
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<taxonomicName id="4C4D12E6FFF1DC51FB02B5D9B8361D45" box="[1213,1318,1270,1289]" class="Liliopsida" family="Zingiberaceae" genus="Alpinia" kingdom="Plantae" order="Zingiberales" pageId="6" pageNumber="7" phylum="Tracheophyta" rank="species" species="zerumbet">
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<emphasis id="B939B577FFF1DC51FB02B5D9B8361D45" bold="true" box="[1213,1318,1270,1289]" italics="true" pageId="6" pageNumber="7">A. zerumbet</emphasis>
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</taxonomicName>
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leaves extract (de Moura et al., 2005). Studies on the hypotensive activity of the purified flavonoids have been cited above (see
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<taxonomicName id="4C4D12E6FFF1DC51FB13B401B9E31D0D" box="[1196,1267,1326,1345]" class="Magnoliopsida" family="Moraceae" genus="Morus" kingdom="Plantae" order="Rosales" pageId="6" pageNumber="7" phylum="Tracheophyta" rank="species" species="alba">
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<emphasis id="B939B577FFF1DC51FB13B401B9E31D0D" bold="true" box="[1196,1267,1326,1345]" italics="true" pageId="6" pageNumber="7">M. alba</emphasis>
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</taxonomicName>
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). Here, two recent researches have to be mentioned which demonstrate the ACE inhibition activity of catechin (He, 2017) and the NO levels stimulation by epicatechin (
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<figureCitation id="137675E0FFF1DC51FC2FB4AEBED61DD8" box="[912,966,1409,1428]" captionStart="Fig" captionStartId="6.[189,219,1965,1982]" captionTargetBox="[189,1398,1653,1943]" captionTargetId="graphics-1010@6.[681,960,1722,1883]" captionTargetPageId="6" captionText="Fig. 7. Singly studied constituents of Alpinia zerumbet (Pers.) B.L.Burtt & R.M.Sm. essential oil (monoterpenes) and leaves extract (flavanols)." figureDoi="http://doi.org/10.5281/zenodo.8293012" httpUri="https://zenodo.org/record/8293012/files/figure.png" pageId="6" pageNumber="7">Fig. 7</figureCitation>
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) (Ramirez-Sanchez et al., 2018).
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</paragraph>
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<paragraph id="8BF26965FFF1DC50FCECB4B2BDB21916" blockId="6.[818,1488,852,1624]" lastBlockId="7.[100,770,159,457]" lastPageId="7" lastPageNumber="8" pageId="6" pageNumber="7">
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Essential oil, obtained by leaves, is also used. This contains a wide range of monoterpenes, of which terpinen-4-ol and 1,8-cineol are the main constituents (
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<figureCitation id="137675E0FFF1DC51FC58B4FAB90D1DA4" box="[999,1053,1493,1512]" captionStart="Fig" captionStartId="6.[189,219,1965,1982]" captionTargetBox="[189,1398,1653,1943]" captionTargetId="graphics-1010@6.[681,960,1722,1883]" captionTargetPageId="6" captionText="Fig. 7. Singly studied constituents of Alpinia zerumbet (Pers.) B.L.Burtt & R.M.Sm. essential oil (monoterpenes) and leaves extract (flavanols)." figureDoi="http://doi.org/10.5281/zenodo.8293012" httpUri="https://zenodo.org/record/8293012/files/figure.png" pageId="6" pageNumber="7">Fig. 7</figureCitation>
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) (Lahlou et al., 2003; Pinto et al., 2009). The i.
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<taxonomicName id="4C4D12E6FFF1DC51FC82B4DEBEF61E48" box="[829,998,1521,1540]" pageId="6" pageNumber="7" rank="variety" variety="administration">v. administration</taxonomicName>
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of the
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<taxonomicName id="4C4D12E6FFF1DC51FB81B4DEB9A01E48" box="[1086,1200,1521,1540]" class="Liliopsida" family="Zingiberaceae" genus="Alpinia" kingdom="Plantae" order="Zingiberales" pageId="6" pageNumber="7" phylum="Tracheophyta" rank="species" species="zerumbet">
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<emphasis id="B939B577FFF1DC51FB81B4DEB9A01E48" bold="true" box="[1086,1200,1521,1540]" italics="true" pageId="6" pageNumber="7">A. zerumbet</emphasis>
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</taxonomicName>
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essential oil to both Deoxycorticosterone acetate (DOCA) salt hypertensive and uninephrectomized, normotensive rats results in a decrease of BP (Lahlou et al., 2003), mainly due to terpinen-4-ol. The vasorelaxant effect occurs also by an endothelium-independent mechanism, as
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<taxonomicName id="4C4D12E6FFF0DC50FD28B1B0BE1118FE" box="[663,769,159,178]" class="Liliopsida" family="Zingiberaceae" genus="Alpinia" kingdom="Plantae" order="Zingiberales" pageId="7" pageNumber="8" phylum="Tracheophyta" rank="species" species="zerumbet">
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<emphasis id="B939B577FFF0DC50FD28B1B0BE1118FE" bold="true" box="[663,769,159,178]" italics="true" pageId="7" pageNumber="8">A. zerumbet</emphasis>
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</taxonomicName>
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essential oil methanolic fraction, rich in terpinen-4-ol and 1,8-cineol, inhibits calcium influx, acting on receptor-operated calcium channels and voltage-operated calcium channels (VOCC) (da
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<collectingCountry id="F35A29F5FFF0DC50FDF6B1DCBF95194A" box="[585,645,243,262]" name="Saint Helena, Ascension and Tristan da Cunha" pageId="7" pageNumber="8">Cunha</collectingCountry>
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et al., 2013). Recently, terpinen-4-ol has been proved to change intracellular Ca
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<superScript id="7C38C42DFFF0DC50FD56B025BE12195B" attach="left" box="[745,770,266,279]" fontSize="5" pageId="7" pageNumber="8">2+</superScript>
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handling and to induce pacing disturbance in rat hearts (Gondim et al., 2017).
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</paragraph>
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<caption id="DF3239EDFFF1DC51FF02B682B8681FF2" ID-DOI="http://doi.org/10.5281/zenodo.8293012" ID-Zenodo-Dep="8293012" box="[189,1400,1965,1982]" httpUri="https://zenodo.org/record/8293012/files/figure.png" pageId="6" pageNumber="7" startId="6.[189,219,1965,1982]" targetBox="[189,1398,1653,1943]" targetPageId="6" targetType="figure">
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<paragraph id="8BF26965FFF1DC51FF02B682B8681FF2" blockId="6.[189,1400,1965,1982]" box="[189,1400,1965,1982]" pageId="6" pageNumber="7">
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<emphasis id="B939B577FFF1DC51FF02B682BDE71FF2" bold="true" box="[189,247,1965,1982]" pageId="6" pageNumber="7">Fig. 7.</emphasis>
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Singly studied constituents of
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<taxonomicName id="4C4D12E6FFF1DC51FE40B682BE6A1FF2" authority="(Pers.) B. L. Burtt & R. M. Sm." authorityName="B. L. Burtt & R. M. Sm." baseAuthorityName="Pers." box="[511,890,1965,1982]" class="Liliopsida" family="Zingiberaceae" genus="Alpinia" kingdom="Plantae" order="Zingiberales" pageId="6" pageNumber="7" phylum="Tracheophyta" rank="species" species="zerumbet">
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<emphasis id="B939B577FFF1DC51FE40B682BF971FF2" bold="true" box="[511,647,1965,1982]" italics="true" pageId="6" pageNumber="7">Alpinia zerumbet</emphasis>
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(Pers.) B.L.Burtt & R.M.Sm.
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</taxonomicName>
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essential oil (monoterpenes) and leaves extract (flavanols).
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</paragraph>
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</caption>
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<paragraph id="8BF26965FFF0DC50FF3AB04CBDB21985" blockId="7.[100,770,159,457]" pageId="7" pageNumber="8">The plant has also properties of inhibiting the ox-LDL-mediated dysfunction of the vascular endothelium (Shen et al., 2012). In humans, the essential oil has effect on post-stroke muscle spasticity (Maia et al., 2016).</paragraph>
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</subSubSection>
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</treatment>
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</document> |