treatments-xml/data/03/85/EF/0385EF62FF90FF83FFC7D78EFDAC33B5.xml
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<mods:title id="3CCA57D31727A394F6BF8203176433BC">Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties</mods:title>
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<mods:namePart id="714C986DDC79589131C6E9CCE853375D">Fiorito, Serena</mods:namePart>
<mods:affiliation id="0F07BA36E987AF513B34A938FC7DE9CC">Dipartimento di Farmacia, Università “ G. dAnnunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy &amp; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia, Italy</mods:affiliation>
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<mods:affiliation id="DA80FA14DE896ADC8FA9447AC30DFE3C">Dipartimento di Farmacia, Università “ G. dAnnunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:affiliation id="F524E59159BD340AFD9DC5C6E5284AE5">Dipartimento di Farmacia, Università “ G. dAnnunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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5.4.1.
<taxonomicName id="4C2C25F7FF90FF83FF07D78EFE2331D2" ID-CoL="6G6L8" authority="C. Morren" authorityName="C. Morren" box="[164,483,215,234]" class="Magnoliopsida" family="Berberidaceae" genus="Epimedium" kingdom="Plantae" order="Ranunculales" pageId="4" pageNumber="5" phylum="Tracheophyta" rank="species" species="grandiflorum">Epimedium grandiflorum C. Morren</taxonomicName>
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<taxonomicName id="4C2C25F7FF90FF83FF26D7AAFED3303E" box="[133,275,243,262]" class="Magnoliopsida" family="Berberidaceae" genus="Epimedium" kingdom="Plantae" order="Ranunculales" pageId="4" pageNumber="5" phylum="Tracheophyta" rank="species" species="grandiflorum">
<emphasis id="B9588266FF90FF83FF26D7AAFED3303E" bold="true" box="[133,275,243,262]" italics="true" pageId="4" pageNumber="5">E. grandiflorum</emphasis>
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(bishop's hat) is a plant used in the Chinese traditional medicine and the polysaccharide fraction of which represents the main biologically active component (
<bibRefCitation id="EFBD2385FF90FF83FE62D672FDA53006" author="Liang, Q. &amp; Wei, G. &amp; Chen, J. &amp; Wang, Y. &amp; Huang, H." box="[449,613,299,318]" pageId="4" pageNumber="5" pagination="13345 - 13356" refId="ref11809" refString="Liang, Q., Wei, G., Chen, J., Wang, Y., Huang, H., 2012. Variation of medicinal components in a unique geographical accession of horny goat weed Epimedium sagittatum Maxim. (Berberidaceae). Molecules 17, 13345 - 13356." type="journal article" year="2012">Liang et al., 2012</bibRefCitation>
). In 2016 Li and coworkers synthesized a library of 9 Se-Ps samples from polysaccharides extracted from roots of this species getting yields in the range 19.5%36.5% and Se contents of
<quantity id="4CD4F391FF90FF83FE45D626FDF430AA" box="[486,564,383,402]" metricMagnitude="-6" metricUnit="kg" metricValue="2.65" pageId="4" pageNumber="5" unit="mg" value="2.65">2.65 mg</quantity>
/g -
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/g. Subsequently, the immune-enhancing capacities, expressed as the extent of chicken peripheral lymphocytes proliferation, were measured using doses from 0.098 μg/mL to 1.563 μg/mL (
<bibRefCitation id="EFBD2385FF90FF83FDA7D68BFD5330DD" author="Li, X. &amp; Hou, R. &amp; Yue, C. &amp; Liu, J. &amp; Gao, Z. &amp; Chen, J. &amp; Lu, Y. &amp; Wang, D. &amp; Liu, C. &amp; Hu, Y." box="[516,659,466,485]" pageId="4" pageNumber="5" pagination="224 - 234" refId="ref11725" refString="Li, X., Hou, R., Yue, C., Liu, J., Gao, Z., Chen, J., Lu, Y., Wang, D., Liu, C., Hu, Y., 2016. The selenylation modification of Epimedium polysaccharide and Isatis root polysaccharide and the immune-enhancing activity comparison of their modifiers. Biol. Trace Elem. Res. 171, 224 - 234." type="journal article" year="2016">Li et al., 2016</bibRefCitation>
). The Se-P having a Se content of
<quantity id="4CD4F391FF90FF83FEE2D6B7FE433339" box="[321,387,494,513]" metricMagnitude="-6" metricUnit="kg" metricValue="7.2" pageId="4" pageNumber="5" unit="mg" value="7.2">7.2 mg</quantity>
/g displayed the best activity, leading to the highest degree of proliferation (25.5%) and was then selected to perform further tests. The same pattern was recorded in
<emphasis id="B9588266FF90FF83FD27D57FFD003301" bold="true" box="[644,704,550,569]" italics="true" pageId="4" pageNumber="5">in vivo</emphasis>
assays using ND vaccinated 1-day old White Roman male chickens fed with the Se-P dissolved in water for 28 days. The best increase of proliferation rate was observed after 2 weeks of treatment (50.1%).
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