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<mods:title id="DF7B78574910D8A7C5DBD8BDB1C21BA5">Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties</mods:title>
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<mods:namePart id="DAB3A60564B10AEDDB11253481A97B41">Fiorito, Serena</mods:namePart>
<mods:affiliation id="7D1C5B0598BD28966123ACF215B64254">Dipartimento di Farmacia, Università “ G. dAnnunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy &amp; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia, Italy</mods:affiliation>
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<mods:namePart id="4D11118D4DB67AE915B4D1BD3FE9D39D">Epifano, Francesco</mods:namePart>
<mods:affiliation id="0441B89E51686DBE8F0D414CE4E69167">Dipartimento di Farmacia, Università “ G. dAnnunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="7390A841476EF43B469F6BED65E76B04">Preziuso, Francesca</mods:namePart>
<mods:affiliation id="D3B53A468C957E9C4D107A3E0E18A7B8">Dipartimento di Farmacia, Università “ G. dAnnunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="6F9030BD28F9D654F27FF9578A3DA5A5">Taddeo, Vito Alessandro</mods:namePart>
<mods:affiliation id="F7A4A299B3C91E99E3E1BD99BFE2E5CB">Dipartimento di Farmacia, Università “ G. dAnnunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="EBD1289F81F81165CD6E902805465535">Genovese, Salvatore</mods:namePart>
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<treatment id="0385EF62FF90FF83FC91D626FB3B3517" LSID="urn:lsid:plazi:treatment:0385EF62FF90FF83FC91D626FB3B3517" httpUri="http://treatment.plazi.org/id/0385EF62FF90FF83FC91D626FB3B3517" lastPageNumber="5" pageId="4" pageNumber="5">
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<emphasis id="B9588266FF90FF83FC91D626FB5A30AA" bold="true" box="[818,1178,383,402]" italics="true" pageId="4" pageNumber="5">
5.8.1.
<taxonomicName id="4C2C25F7FF90FF83FCD1D626FB5A30AA" ID-CoL="5W4MR" authority="Krasch" authorityName="Krasch" box="[882,1178,383,402]" class="Magnoliopsida" family="Asteraceae" genus="Artemisia" kingdom="Plantae" order="Asterales" pageId="4" pageNumber="5" phylum="Tracheophyta" rank="species" species="sphaerocephala">Artemisia sphaerocephala Krasch</taxonomicName>
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<taxonomicName id="4C2C25F7FF90FF83FCF0D6C3FC353095" box="[851,1013,410,429]" class="Magnoliopsida" family="Asteraceae" genus="Artemisia" kingdom="Plantae" order="Asterales" pageId="4" pageNumber="5" phylum="Tracheophyta" rank="species" species="sphaerocephala">
<emphasis id="B9588266FF90FF83FCF0D6C3FC353095" bold="true" box="[851,1013,410,429]" italics="true" pageId="4" pageNumber="5">A. sphaerocephala</emphasis>
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is a plant endemic of
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and widely used in this area as food. Polysaccharides from this plant have been reported to possess anti-oxidant activity (
<bibRefCitation id="EFBD2385FF90FF83FBF2D68BFAC130DD" author="Wang, J. &amp; Zhang, J. &amp; Wang, X. &amp; Zhao, B. &amp; Wu, Y. &amp; Yao, J." box="[1105,1281,466,485]" pageId="4" pageNumber="5" pagination="483 - 492" refId="ref13235" refString="Wang, J., Zhang, J., Wang, X., Zhao, B., Wu, Y., Yao, J., 2009. A comparison study on microwave-assisted extraction of Artemisia sphaerocephala polysaccharide with conventional method. Molecule structure and antioxidant activity evaluation. Int. J. Macromol. Biol. 45, 483 - 492." type="journal article" year="2009">Wang et al., 2009</bibRefCitation>
). In 2012 Wang and coworkers synthesized a library of 6 Se-Ps using the extract of the whole plant as starting material with a Se content ranging from
<quantity id="4CD4F391FF90FF83FAF6D553FA633325" box="[1365,1443,522,541]" metricMagnitude="-7" metricUnit="kg" metricValue="1.7" pageId="4" pageNumber="5" unit="mg" value="0.17">0.17 mg</quantity>
/g to
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/g. These samples were preliminarily tested
<emphasis id="B9588266FF90FF83FAAED57FFA8B3301" bold="true" box="[1293,1355,550,569]" italics="true" pageId="4" pageNumber="5">in vitro</emphasis>
as scavengers of DPPH radical and superoxide anions and for their reducing power, and ability to chelate ferrous ions. All Se-Ps synthesized showed a dose-dependent anti-oxidant capacity in the range
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/mL. The native polysaccharide exhibited much lower values. On the other hand, a low chelating ability and reducing power were observed. These results were complemented by anti-tumor studies accomplished in 2016 by the same research group (
<bibRefCitation id="EFBD2385FF90FF83FC70D5B0FB4433C4" author="Wang, J. &amp; Li, Q. &amp; Bao, A. &amp; Liu, Z. &amp; Zeng, J. &amp; Yang, X. &amp; Yao, J. &amp; Zhang, J. &amp; Lei, Z." box="[979,1156,745,764]" pageId="4" pageNumber="5" pagination="70 - 78" refId="ref13429" refString="Wang, J., Li, Q., Bao, A., Liu, Z., Zeng, J., Yang, X., Yao, J., Zhang, J., Lei, Z., 2016. Synthesis of selenium containing solution: conformation and anti-tumor activities. Carbohydr. Polym. 152, 70 - 78." type="journal article" year="2016">Wang et al., 2016</bibRefCitation>
). The Se-P exhibiting the highest effect in
<emphasis id="B9588266FF90FF83FC24D45CFC073220" bold="true" box="[903,967,773,792]" italics="true" pageId="4" pageNumber="5">in vitro</emphasis>
assays was selected and seen to effectively inhibit the growth of HeLa (cervical cancer), A549 (lung carcinoma), and HepG2 (human hepatoma) cancer cell lines in a dose dependent-manner in the concentration range 25500 μg/mL. Finally, in 2017 Wang and coworkers reported the first synthesis of Se-Ps from
<taxonomicName id="4C2C25F7FF90FF83FAABD42CFA6C32B0" box="[1288,1452,885,904]" class="Magnoliopsida" family="Asteraceae" genus="Artemisia" kingdom="Plantae" order="Asterales" pageId="4" pageNumber="5" phylum="Tracheophyta" rank="species" species="sphaerocephala">
<emphasis id="B9588266FF90FF83FAABD42CFA6C32B0" bold="true" box="[1288,1452,885,904]" italics="true" pageId="4" pageNumber="5">A. sphaerocephala</emphasis>
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assisted by microwaves. However, although yields were very high (72.1%94.9%), the Se content was rather low (&lt;264 μg/g). The 7 samples obtained were then screened as growth inhibitory agents against H1650 cancer cell line (human non-small cell lung cancer), but the best effect recorded was modest (32.4% and 39.8% growth inhibition at 100 μg/mL and 200 μg/mL respectively).
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