240 lines
24 KiB
XML
240 lines
24 KiB
XML
<document id="E362575F352829DA0DED1CF71E7A0FEE" ID-CLB-Dataset="264564" ID-DOI="10.1016/j.phytochem.2019.112222" ID-GBIF-Dataset="4a860314-bd9c-4c55-9f10-852e402b1aef" ID-ISSN="1873-3700" ID-Zenodo-Dep="8292998" IM.illustrations_approvedBy="carolina" IM.materialsCitations_approvedBy="felipe" IM.metadata_approvedBy="felipe" IM.taxonomicNames_approvedBy="carolina" IM.treatments_approvedBy="carolina" checkinTime="1693250931468" checkinUser="felipe" docAuthor="Micucci, M., Bolchi, C., Budriesi, R., Cevenini, M., Maroni, L., Capozza, S., Chiarini, A., Pallavicini, M. & Angeletti, A." docDate="2020" docId="03E4D873FFF4DC53FC8DB1B0BFD91C0F" docLanguage="en" docName="Phytochemistry.170.112222.pdf" docOrigin="Phytochemistry (112222) 170" docSource="http://dx.doi.org/10.1016/j.phytochem.2019.112222" docStyle="DocumentStyle:F36D69FC8B198FBE91029DF9C24697D3.5:Phytochemistry.2020-.journal_article" docStyleId="F36D69FC8B198FBE91029DF9C24697D3" docStyleName="Phytochemistry.2020-.journal_article" docStyleVersion="5" docTitle="Hibiscus sabdari L." docType="treatment" docVersion="4" lastPageNumber="4" masterDocId="FFDDA00BFFF7DC57FFBFB12FBD10184C" masterDocTitle="Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents" masterLastPageNumber="19" masterPageNumber="1" pageNumber="4" updateTime="1693417694953" updateUser="ExternalLinkService">
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<mods:title id="1249433B7E39E7A89220204EE7D2D794">Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents</mods:title>
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<mods:namePart id="24F2D5576CAC053EEB6645028ED4C406">Micucci, M.</mods:namePart>
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<mods:affiliation id="79C2F70AB711A183A89467DE32D31C53">∗ & Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro, 6, 40126, Italy</mods:affiliation>
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<mods:namePart id="E29E1AAF5B0F0D3372D5101B9D1C5C70">Budriesi, R.</mods:namePart>
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<mods:namePart id="4E9FA0E27924ED614FB24609941A65F1">Cevenini, M.</mods:namePart>
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<mods:namePart id="ED1C4A60C6BB2BAD29E0FACB81639BA6">Maroni, L.</mods:namePart>
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<mods:namePart id="F2A02DDCC646D875B177322643FD86FA">Capozza, S.</mods:namePart>
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<mods:namePart id="FE598BD5968AB8FE65C0B7C22417E7D2">Chiarini, A.</mods:namePart>
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<mods:title id="692E4C1BD32E759CBD360A17536C20DD">Phytochemistry</mods:title>
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<mods:date id="43B4A32A12E9A7002C17745C8F663A1E">2020</mods:date>
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<mods:identifier id="7A344CB69810B16CCA80189262BEA753" type="DOI">10.1016/j.phytochem.2019.112222</mods:identifier>
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<treatment id="03E4D873FFF4DC53FC8DB1B0BFD91C0F" ID-DOI="http://doi.org/10.5281/zenodo.8302632" ID-Zenodo-Dep="8302632" LSID="urn:lsid:plazi:treatment:03E4D873FFF4DC53FC8DB1B0BFD91C0F" httpUri="http://treatment.plazi.org/id/03E4D873FFF4DC53FC8DB1B0BFD91C0F" lastPageId="4" lastPageNumber="4" pageId="3" pageNumber="4">
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<subSubSection id="C3573AEEFFF4DC54FC8DB1B0B90C18FE" box="[818,1052,159,178]" pageId="3" pageNumber="4" type="nomenclature">
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<paragraph id="8BF26965FFF4DC54FC8DB1B0B90C18FE" blockId="3.[818,1052,159,178]" box="[818,1052,159,178]" pageId="3" pageNumber="4">
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<emphasis id="B939B577FFF4DC54FC8DB1B0BE4518FE" bold="true" box="[818,853,159,178]" italics="true" pageId="3" pageNumber="4">2.3.</emphasis>
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<taxonomicName id="4C4D12E6FFF4DC54FCDFB1B0B90C18FE" authority="L." authorityName="L." box="[864,1052,159,178]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
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Hibiscus sabdari ff
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<emphasis id="B939B577FFF4DC54FC40B1B0B90C18FE" bold="true" box="[1023,1052,159,178]" italics="true" pageId="3" pageNumber="4">a L</emphasis>
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</taxonomicName>
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</paragraph>
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</subSubSection>
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<subSubSection id="C3573AEEFFF4DC53FCECB1F8BFD91C0F" lastPageId="4" lastPageNumber="5" pageId="3" pageNumber="4" type="description">
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<paragraph id="8BF26965FFF4DC54FCECB1F8B9AF1916" blockId="3.[818,1488,215,1992]" pageId="3" pageNumber="4">
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<taxonomicName id="4C4D12E6FFF4DC54FCECB1F8BEEE18A6" box="[851,1022,215,234]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
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<emphasis id="B939B577FFF4DC54FCECB1F8BEEE18A6" box="[851,1022,215,234]" italics="true" pageId="3" pageNumber="4">
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<emphasis id="B939B577FFF4DC54FCECB1F8BEF518A6" bold="true" box="[851,997,215,234]" italics="true" pageId="3" pageNumber="4">Hibiscus sabdari</emphasis>
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ff
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<emphasis id="B939B577FFF4DC54FC4CB1F8BEEE18A6" bold="true" box="[1011,1022,215,234]" italics="true" pageId="3" pageNumber="4">a</emphasis>
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</emphasis>
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</taxonomicName>
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L. (Syn: Roselle, Rozelle, Indian sorrel, Sour tea and Karkade) has been used for several purposes in folk medicine. In
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<collectingCountry id="F35A29F5FFF4DC54FC8DB020BE75196E" box="[818,869,271,290]" name="India" pageId="3" pageNumber="4">India</collectingCountry>
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, Africa and
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<collectingCountry id="F35A29F5FFF4DC54FC6CB020B909196E" box="[979,1049,271,290]" name="Mexico" pageId="3" pageNumber="4">Mexico</collectingCountry>
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||
, leaves or calyces are used to prepare infusions that are believed to exert choleretic, febrifugal, diuretic, and hypotensive effects (Da-Costa-Rocha et al., 2014).
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</paragraph>
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<paragraph id="8BF26965FFF4DC54FCECB04CBE7F1A4D" blockId="3.[818,1488,215,1992]" pageId="3" pageNumber="4">
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The chemical composition of
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<emphasis id="B939B577FFF4DC54FBD9B04CB9CB193A" box="[1126,1243,354,374]" italics="true" pageId="3" pageNumber="4">
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<taxonomicName id="4C4D12E6FFF4DC54FBD9B04CB9D3193A" box="[1126,1219,355,374]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
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<emphasis id="B939B577FFF4DC54FBD9B04CB9D3193A" bold="true" box="[1126,1219,355,374]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
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</taxonomicName>
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ff
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<emphasis id="B939B577FFF4DC54FB6FB04CB9CB193A" bold="true" box="[1232,1243,355,374]" italics="true" pageId="3" pageNumber="4">a</emphasis>
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</emphasis>
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extracts includes hibiscus acid, hibiscus acid glucosides, caffeoylquinic acids, flavonoids such as quercetin-3-rutinoside, kaempferol-3-O-rutinoside, myricetin, anthocyanins such as delphinidin-3-sambubioside and cyanidin-3-sambubioside (
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<figureCitation id="137675E0FFF4DC54FC3CB0FDBEA819A9" box="[899,952,466,485]" captionStart="Fig" captionStartId="4.[155,185,981,998]" captionTargetBox="[227,1361,152,958]" captionTargetPageId="4" captionText="Fig. 3. Chemical structure of the compounds contained in Hibiscus sabdariffa L. extracts whose vascular and blood pressure effects were investigated." figureDoi="http://doi.org/10.5281/zenodo.8293004" httpUri="https://zenodo.org/record/8293004/files/figure.png" pageId="3" pageNumber="4">Fig. 3</figureCitation>
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) (Da-Costa-Rocha et al., 2014; Ramirez-Rodrigues et al., 2011).
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</paragraph>
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<paragraph id="8BF26965FFF4DC54FCECB325B9541A3D" blockId="3.[818,1488,215,1992]" pageId="3" pageNumber="4">
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<emphasis id="B939B577FFF4DC54FCECB325BEDB1A51" box="[851,971,522,541]" italics="true" pageId="3" pageNumber="4">
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<taxonomicName id="4C4D12E6FFF4DC54FCECB325BEA21A51" box="[851,946,522,541]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
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<emphasis id="B939B577FFF4DC54FCECB325BEA21A51" bold="true" box="[851,946,522,541]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
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</taxonomicName>
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ff
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<emphasis id="B939B577FFF4DC54FC7FB325BEDB1A51" bold="true" box="[960,971,522,541]" italics="true" pageId="3" pageNumber="4">a</emphasis>
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</emphasis>
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tea has been shown to be able to lower food intake, decrease lipogenesis, increase lipolysis, stimulate fatty acids β- oxidation and attenuate inflammatory responses and oxidative stress (Herranz-Lopez et al., 2017).
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</paragraph>
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<paragraph id="8BF26965FFF4DC54FCECB355B9051B97" blockId="3.[818,1488,215,1992]" pageId="3" pageNumber="4">
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<emphasis id="B939B577FFF4DC54FCECB355BED81AC1" box="[851,968,633,653]" italics="true" pageId="3" pageNumber="4">
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<taxonomicName id="4C4D12E6FFF4DC54FCECB355BEBF1AC1" box="[851,943,634,653]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
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<emphasis id="B939B577FFF4DC54FCECB355BEBF1AC1" bold="true" box="[851,943,634,653]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
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</taxonomicName>
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ff
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<emphasis id="B939B577FFF4DC54FC02B355BED81AC1" bold="true" box="[957,968,634,653]" italics="true" pageId="3" pageNumber="4">a</emphasis>
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</emphasis>
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extracts decrease BP in normotensive and hypertensive animals by several mechanisms (Mojiminiyi et al., 2007; Onyenekwe et al., 1999). A methanolic extract from
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<emphasis id="B939B577FFF4DC54FB03B39EB8241A88" box="[1212,1332,689,708]" italics="true" pageId="3" pageNumber="4">
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<taxonomicName id="4C4D12E6FFF4DC54FB03B39EB80B1A88" box="[1212,1307,689,708]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
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<emphasis id="B939B577FFF4DC54FB03B39EB80B1A88" bold="true" box="[1212,1307,689,708]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
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</taxonomicName>
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ff
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<emphasis id="B939B577FFF4DC54FA96B39EB8241A88" bold="true" box="[1321,1332,689,708]" italics="true" pageId="3" pageNumber="4">a</emphasis>
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</emphasis>
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calyces reduces the rat aorta rings contractions induced by KCl and phenylephrine (Ajay et al., 2007), suggesting its ability to inhibit calcium influx. The relaxant effect of the hibiscus flower extract was also observed in guinea pig aorta and ileum, where it exerts a calcium antagonistic effect (Micucci et al., 2015). In addition, it was also demonstrated that the vasorelaxation was possibly mediated by the endothelium-derived nitric oxide-cGMP-relaxant pathway and by the inhibition of calciuminflux into vascular smooth muscle cells, as it was inhibited by removal of endothelium and by the presence of atropine, L-NAME or methylene blue (Ajay et al., 2007).
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</paragraph>
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<paragraph id="8BF26965FFF4DC54FCECB2CBB8611C63" blockId="3.[818,1488,215,1992]" pageId="3" pageNumber="4">
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Another effect responsible for the hypotensive activity is ACE inhibition, which is due, at least in part, to delphinidin-3-sambubioside and cyanidin-3-O-sambubioside (
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<figureCitation id="137675E0FFF4DC54FBD3B533B9B21C63" box="[1132,1186,1052,1071]" captionStart="Fig" captionStartId="4.[155,185,981,998]" captionTargetBox="[227,1361,152,958]" captionTargetPageId="4" captionText="Fig. 3. Chemical structure of the compounds contained in Hibiscus sabdariffa L. extracts whose vascular and blood pressure effects were investigated." figureDoi="http://doi.org/10.5281/zenodo.8293004" httpUri="https://zenodo.org/record/8293004/files/figure.png" pageId="3" pageNumber="4">Fig. 3</figureCitation>
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) (Ojeda et al., 2010).
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</paragraph>
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<paragraph id="8BF26965FFF4DC54FCECB517B9AD1D66" blockId="3.[818,1488,215,1992]" pageId="3" pageNumber="4">
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<emphasis id="B939B577FFF4DC54FCECB517BE9E1C07" bold="true" box="[851,910,1080,1099]" italics="true" pageId="3" pageNumber="4">In vivo</emphasis>
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experiments demonstrated that the oral administration of the water extract from
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<emphasis id="B939B577FFF4DC54FC5AB57BB9491C2B" box="[997,1113,1108,1127]" italics="true" pageId="3" pageNumber="4">
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<taxonomicName id="4C4D12E6FFF4DC54FC5AB57BB9501C2B" box="[997,1088,1108,1127]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
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<emphasis id="B939B577FFF4DC54FC5AB57BB9501C2B" bold="true" box="[997,1088,1108,1127]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
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</taxonomicName>
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ff
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<emphasis id="B939B577FFF4DC54FBF1B57BB9491C2B" bold="true" box="[1102,1113,1108,1127]" italics="true" pageId="3" pageNumber="4">a</emphasis>
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</emphasis>
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calyces to male albino Sprague–Dawley rats causes a diuretic effect (Alarcon-Alonso et al., 2012) probably related to quercetin. Polyphenol water extract, in fact, seems to inhibit ATPase activity (Mezesova et al., 2010) affecting the Na
|
||
<superScript id="7C38C42DFFF4DC54FADBB58CB8641CFC" attach="left" box="[1380,1396,1187,1200]" fontSize="5" pageId="3" pageNumber="4">+</superScript>
|
||
/K
|
||
<superScript id="7C38C42DFFF4DC54FA33B58CB88C1CFC" attach="left" box="[1420,1436,1187,1200]" fontSize="5" pageId="3" pageNumber="4">+</superScript>
|
||
concentration gradient in nephron tubular segment epithelial cells. In addition, the diuretic- as well as natriuretic- and potassium sparing-effects of the extract seems to be due to
|
||
<emphasis id="B939B577FFF4DC54FBCCB5D4B9F91D42" box="[1139,1257,1275,1294]" italics="true" pageId="3" pageNumber="4">
|
||
<taxonomicName id="4C4D12E6FFF4DC54FBCCB5D4B9C01D42" box="[1139,1232,1275,1294]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
|
||
<emphasis id="B939B577FFF4DC54FBCCB5D4B9C01D42" bold="true" box="[1139,1232,1275,1294]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
|
||
</taxonomicName>
|
||
ff
|
||
<emphasis id="B939B577FFF4DC54FB61B5D4B9F91D42" bold="true" box="[1246,1257,1275,1294]" italics="true" pageId="3" pageNumber="4">a</emphasis>
|
||
</emphasis>
|
||
ability to downregulate aldosterone (Jimenez-Ferrer et al., 2012).
|
||
</paragraph>
|
||
<paragraph id="8BF26965FFF4DC54FCECB41CB9201E35" blockId="3.[818,1488,215,1992]" pageId="3" pageNumber="4">
|
||
Interestingly, the hypotensive activity was observed also in humans (Nwachukwu et al., 2015). In particular, clinical studies demonstrated that the administration of
|
||
<emphasis id="B939B577FFF4DC54FB98B444B98B1D32" box="[1063,1179,1386,1406]" italics="true" pageId="3" pageNumber="4">
|
||
<taxonomicName id="4C4D12E6FFF4DC54FB98B444B9921D32" box="[1063,1154,1387,1406]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
|
||
<emphasis id="B939B577FFF4DC54FB98B444B9921D32" bold="true" box="[1063,1154,1387,1406]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
|
||
</taxonomicName>
|
||
ff
|
||
<emphasis id="B939B577FFF4DC54FB2FB444B98B1D32" bold="true" box="[1168,1179,1387,1406]" italics="true" pageId="3" pageNumber="4">a</emphasis>
|
||
</emphasis>
|
||
extracts to hypertensive patients reduces BP (Nwachukwu et al., 2015, 2017; Herrera-Arellano et al., 2004, 2007; McKay et al., 2010). In a double-blind placebo-controlled clinical trial, daily consumption of
|
||
<emphasis id="B939B577FFF4DC54FB34B490B8141D9E" box="[1163,1284,1470,1490]" italics="true" pageId="3" pageNumber="4">
|
||
<taxonomicName id="4C4D12E6FFF4DC54FB34B490B9FB1D9E" box="[1163,1259,1471,1490]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
|
||
<emphasis id="B939B577FFF4DC54FB34B490B9FB1D9E" bold="true" box="[1163,1259,1471,1490]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
|
||
</taxonomicName>
|
||
ff
|
||
<emphasis id="B939B577FFF4DC54FB46B490B8141D9E" bold="true" box="[1273,1284,1471,1490]" italics="true" pageId="3" pageNumber="4">a</emphasis>
|
||
</emphasis>
|
||
L. calyx powder decreased systolic BP and serum triglycerides in metabolic syndrome patients (Asgary et al., 2016). In addition, the polyphenol content influences the course of obesity (Rodriguez-Perez et al., 2017). Moreover,
|
||
<emphasis id="B939B577FFF4DC54FC8DB701BECB1E0D" box="[818,987,1582,1601]" italics="true" pageId="3" pageNumber="4">
|
||
<taxonomicName id="4C4D12E6FFF4DC54FC8DB701BED21E0D" box="[818,962,1582,1601]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
|
||
<emphasis id="B939B577FFF4DC54FC8DB701BED21E0D" bold="true" box="[818,962,1582,1601]" italics="true" pageId="3" pageNumber="4">Hibiscus sabdari</emphasis>
|
||
</taxonomicName>
|
||
ff
|
||
<emphasis id="B939B577FFF4DC54FC6FB701BECB1E0D" bold="true" box="[976,987,1582,1601]" italics="true" pageId="3" pageNumber="4">a</emphasis>
|
||
</emphasis>
|
||
consumption was reported to improve renal function in a population study of Nigerians with mild to moderate hypertension (Nwachukwu et al., 2017).
|
||
</paragraph>
|
||
<paragraph id="8BF26965FFF4DC53FCECB7ADBFD91C0F" blockId="3.[818,1488,215,1992]" lastBlockId="4.[100,769,1044,1091]" lastPageId="4" lastPageNumber="5" pageId="3" pageNumber="4">
|
||
The compounds contained in
|
||
<emphasis id="B939B577FFF4DC54FBD6B7ADB9CF1ED9" box="[1129,1247,1665,1685]" italics="true" pageId="3" pageNumber="4">
|
||
<taxonomicName id="4C4D12E6FFF4DC54FBD6B7ADB9D61ED9" box="[1129,1222,1666,1685]" class="Magnoliopsida" family="Malvaceae" genus="Hibiscus" kingdom="Plantae" order="Malvales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sabdari">
|
||
<emphasis id="B939B577FFF4DC54FBD6B7ADB9D61ED9" bold="true" box="[1129,1222,1666,1685]" italics="true" pageId="3" pageNumber="4">H. sabdari</emphasis>
|
||
</taxonomicName>
|
||
ff
|
||
<emphasis id="B939B577FFF4DC54FB6BB7ADB9CF1ED9" bold="true" box="[1236,1247,1666,1685]" italics="true" pageId="3" pageNumber="4">a</emphasis>
|
||
</emphasis>
|
||
extracts and individually studied for antihypertensive effects are caffeoylquinic acids, in particular the 5-caffeoyl regioisomer, and rutin previously mentioned as active constituents of
|
||
<taxonomicName id="4C4D12E6FFF4DC54FBB1B7FAB9471EA4" box="[1038,1111,1749,1768]" class="Magnoliopsida" family="Moraceae" genus="Morus" kingdom="Plantae" order="Rosales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="alba">
|
||
<emphasis id="B939B577FFF4DC54FBB1B7FAB9471EA4" bold="true" box="[1038,1111,1749,1768]" italics="true" pageId="3" pageNumber="4">M. alba</emphasis>
|
||
</taxonomicName>
|
||
leaves and leaf extracts. In addition, studies have been dedicated to hibiscus acid and garcinia acid, to the flavonoid myricetin and to the glucosides of the anthocyanins delphinidin and cyanidin (
|
||
<figureCitation id="137675E0FFF4DC54FC45B606B9231F70" box="[1018,1075,1833,1852]" captionStart="Fig" captionStartId="4.[155,185,981,998]" captionTargetBox="[227,1361,152,958]" captionTargetPageId="4" captionText="Fig. 3. Chemical structure of the compounds contained in Hibiscus sabdariffa L. extracts whose vascular and blood pressure effects were investigated." figureDoi="http://doi.org/10.5281/zenodo.8293004" httpUri="https://zenodo.org/record/8293004/files/figure.png" pageId="3" pageNumber="4">Fig. 3</figureCitation>
|
||
). The two acids exert vasorelaxant action likely due to the inhibition of Ca
|
||
<superScript id="7C38C42DFFF4DC54FBD6B66FB9921F01" attach="left" box="[1129,1154,1856,1869]" fontSize="5" pageId="3" pageNumber="4">2+</superScript>
|
||
influx via voltage-dependent Ca
|
||
<superScript id="7C38C42DFFF4DC54FA09B66FB8DF1F01" attach="left" box="[1462,1487,1856,1869]" fontSize="5" pageId="3" pageNumber="4">2+</superScript>
|
||
channels (Zheoat et al., 2019). Myricetin has been proved to significantly inhibit atherogenesis (Sasaki et al., 2018) and it could prevent the development of high blood pressure induced by a diet rich in fructose (Godse et al., 2010). Lastly, ACE inhibition and decreasing of its mRNA production have been demonstrated for the two antocyanins and quercetin (Ojeda et al., 2010; Parichatikanond et al., 2012).
|
||
</paragraph>
|
||
</subSubSection>
|
||
</treatment>
|
||
</document> |