144 lines
18 KiB
XML
144 lines
18 KiB
XML
<document id="E38EFE145F3AB806E91D128FE1673926" ID-DOI="10.1016/j.phytochem.2018.05.008" ID-ISSN="1873-3700" ID-Zenodo-Dep="10483984" IM.bibliography_approvedBy="felipe" IM.illustrations_approvedBy="felipe" IM.materialsCitations_approvedBy="juliana" IM.metadata_approvedBy="juliana" IM.taxonomicNames_approvedBy="juliana" IM.treatments_approvedBy="juliana" checkinTime="1704938445945" checkinUser="felipe" docAuthor="Fiorito, Serena, Epifano, Francesco, Preziuso, Francesca, Taddeo, Vito Alessandro & Genovese, Salvatore" docDate="2018" docId="0385EF62FF97FF84FFC7D626FC1231D2" docLanguage="en" docName="Phytochemistry.153.1-10.pdf" docOrigin="Phytochemistry 153" docSource="http://dx.doi.org/10.1016/j.phytochem.2018.05.008" docStyle="DocumentStyle:9E596C34F4E94307D29315B03ACE1007.6:Phytochemistry.2014-2019.journal_article" docStyleId="9E596C34F4E94307D29315B03ACE1007" docStyleName="Phytochemistry.2014-2019.journal_article" docStyleVersion="6" docTitle="Angelica sinensis Diels" docType="treatment" docVersion="1" lastPageNumber="4" masterDocId="FFBC971AFF94FF87FFA3D759FFC03138" masterDocTitle="Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties" masterLastPageNumber="10" masterPageNumber="1" pageNumber="4" updateTime="1705322845058" updateUser="juliana">
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<mods:title id="5900547DA2753AA5D5A0D9647F995394">Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties</mods:title>
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<mods:namePart id="10F2B7147FCF556A051ADA0E024CC642">Fiorito, Serena</mods:namePart>
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<mods:affiliation id="44B973EBE7A026471FA08E2D64980C53">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy & Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia, Italy</mods:affiliation>
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<mods:namePart id="8660FFD80016B8F33F1B33C7318AC1C7">Epifano, Francesco</mods:namePart>
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<mods:affiliation id="3FA016C0C82DADE36FE05B2F4D670672">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="8E364DC6A42F847C64DC17E75B9B24AF">Preziuso, Francesca</mods:namePart>
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<mods:affiliation id="A62671C8B91F96705D4FA4A8D5DD00B6">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="F9450189F452C21F1378AF4276B506E6">Taddeo, Vito Alessandro</mods:namePart>
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<mods:affiliation id="331E425102F63BD8CE54989C1497D58C">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="EDAE11B0C5EBC1354B2692CD1F4BF73A">Genovese, Salvatore</mods:namePart>
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<mods:affiliation id="DAA050B3209A1807795730F076A55113">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:title id="27D79C53E0B790C4925C2FE4D7376390">Phytochemistry</mods:title>
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<mods:date id="48E62841AC88795A78578871DA945A40">2018</mods:date>
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<mods:number id="08F4A74428607DAF693276DC8DCD7881">2018-09-30</mods:number>
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<mods:number id="1E4B2206A5D21468CD3C5760ADA44FA8">153</mods:number>
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<mods:url id="B4ED17F5D58216BB585CFCBB7704C0D8">http://dx.doi.org/10.1016/j.phytochem.2018.05.008</mods:url>
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<mods:classification id="13DDA8BD306A03ACAC40A89916E75394">journal article</mods:classification>
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<mods:identifier id="29EB2DB7F88C07FFB1E98BBDC5563940" type="DOI">10.1016/j.phytochem.2018.05.008</mods:identifier>
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<mods:identifier id="BAE271FE6DD580ABC994A15012F2A6DD" type="ISSN">1873-3700</mods:identifier>
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<treatment id="0385EF62FF97FF84FFC7D626FC1231D2" LSID="urn:lsid:plazi:treatment:0385EF62FF97FF84FFC7D626FC1231D2" httpUri="http://treatment.plazi.org/id/0385EF62FF97FF84FFC7D626FC1231D2" lastPageNumber="4" pageId="3" pageNumber="4">
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<subSubSection id="C3360DFFFF97FF84FFC7D626FE6F30AA" box="[100,431,383,402]" pageId="3" pageNumber="4" type="nomenclature">
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<paragraph id="8B935E74FF97FF84FFC7D626FE6F30AA" blockId="3.[100,431,383,402]" box="[100,431,383,402]" pageId="3" pageNumber="4">
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<heading id="D0DBE918FF97FF84FFC7D626FE6F30AA" bold="true" box="[100,431,383,402]" fontSize="36" level="1" pageId="3" pageNumber="4" reason="1">
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<emphasis id="B9588266FF97FF84FFC7D626FE6F30AA" bold="true" box="[100,431,383,402]" italics="true" pageId="3" pageNumber="4">
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5.2.1.
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<taxonomicName id="4C2C25F7FF97FF84FF07D626FE6F30AA" authority="(Oliv.) Diels" authorityName="Diels" baseAuthorityName="Oliv." box="[164,431,383,402]" class="Liliopsida" family="Amaryllidaceae" genus="Angelica" kingdom="Plantae" order="Asparagales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sinensis">Angelica sinensis (Oliv.) Diels</taxonomicName>
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</emphasis>
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<taxonomicName id="4C2C25F7FF97FF84FF26D6C3FF2A3095" box="[133,234,410,429]" class="Liliopsida" family="Amaryllidaceae" genus="Allium" kingdom="Plantae" order="Asparagales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="sinensis">
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<emphasis id="B9588266FF97FF84FF26D6C3FF2A3095" bold="true" box="[133,234,410,429]" italics="true" pageId="3" pageNumber="4">A. sinensis</emphasis>
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</taxonomicName>
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(Chinese angelica) is among the most widely used worldwide medicinal plant. The use of its polysaccharide fraction for therapeutic purposes has been well documented in the literature (
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<bibRefCitation id="EFBD2385FF97FF84FD40D68BFF133339" author="Xie, J. H. & Jin, M. L. & Morris, G. A. & Zha, X. Q. & Chen, H. Q. & Yi, Y. & Li, J. E. & Wang, Z. J. & Gao, J. & Nie, S. P. & Shang, P. & Xie, M. Y." pageId="3" pageNumber="4" pagination="60 - 84" refId="ref13634" refString="Xie, J. H., Jin, M. L., Morris, G. A., Zha, X. Q., Chen, H. Q., Yi, Y., Li, J. E., Wang, Z. J., Gao, J., Nie, S. P., Shang, P., Xie, M. Y., 2016. Advances on bioactive polysaccharides from medicinal plants. Crit. Rev. Food Sci. Nutr. 56, 60 - 84." type="journal article" year="2016">Xie et al., 2016</bibRefCitation>
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). The chemical synthesis and characterization of pharmacological properties of Se-Ps from this species have been reported in a series of papers published in the literature between 2013 and 2017. The first of these manuscripts was authored by Qin and coworkers in 2013a, b. These researchers first obtained a library of 9 Se-Ps in modest to fairly good yields (18.0%–42.8%) with a Se content ranging from
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/g to 13.0 mg/g. All the synthesized samples were then screened for their capacity to increase the proliferation rate of chicken peripheral lymphocytes when applied in a concentration range from 0.097 μg/mL to 100 μg/mL. All Se-Ps increased this parameter from 11% to 29%, while the parent polymer recorded a percentage around 6%. Three samples, featured by the highest content of Se,
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/g,
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/g, and
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/g respectively, provided the best results in the
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<emphasis id="B9588266FF97FF84FD1DD464FCC13268" bold="true" box="[702,769,829,848]" italics="true" pageId="3" pageNumber="4">in vitro</emphasis>
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assay and were then selected to perform
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<emphasis id="B9588266FF97FF84FDA3D400FDFF3254" bold="true" box="[512,575,857,876]" italics="true" pageId="3" pageNumber="4">in vivo</emphasis>
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studies in chickens vaccinated with ND vaccine (
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<bibRefCitation id="EFBD2385FF97FF84FE23D42CFDE532B0" author="Qin, T. & Chen, J. & Wang, D. & Hu, Y. & Zhang, J. & Wang, M. & Qiu, S. & Gao, Z. & Liu, R. & Yu, Y. & Huang, Y. & Wang, O. & Wang, Q." box="[384,549,885,904]" pageId="3" pageNumber="4" pagination="183 - 187" refId="ref12534" refString="Qin, T., Chen, J., Wang, D., Hu, Y., Zhang, J., Wang, M., Qiu, S., Gao, Z., Liu, R., Yu, Y., Huang, Y., Wang, O., Wang, Q., 2013 b. Selenylation modification can enhance immuno-enhancing activity of Chinese angelica polysaccharides. Carbohydr. Polym. 95, 183 - 187." type="journal article" year="2013">Qin et al., 2013b</bibRefCitation>
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). Two doses,
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/mL and
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/mL, were administered i.m. to male White Roman chickens once a day for 3 days. All samples at both concentrations led to an increase of the peripheral lymphocyte proliferation in percentages ranging from 34.8% to 44%. The same pattern was recorded for serum antibody titer. A 1.5- to 2-fold increase respect to untreated animals in the production of key mediators like IL-6 and IFN-γ was also revealed. The same research group in 2015 investigated the effects of the treatment with the Se-P previously obtained and featured by the highest content of Se (
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/g) on phagocytosis, NO release, and secretion of TNF-α, IL-6, and IL-
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<quantity id="4CD4F391FF97FF84FE8AD3D5FE9735A7" box="[297,343,1164,1183]" metricMagnitude="-1" metricUnit="m" metricValue="2.54" pageId="3" pageNumber="4" unit="in" value="10.0">10 in</quantity>
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murine peritoneal macrophages (
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<bibRefCitation id="EFBD2385FF97FF84FD3DD3D5FF543583" author="Gao, Z. & Liu, K. & Tian, W. & Wang, H. & Liu, Z. & Li, Y. & Li, E. & Liu, C. & Li, X. & Hou, R. & Yue, C. & Wang, D. & Hu, Y." pageId="3" pageNumber="4" pagination="104 - 109" refId="ref10491" refString="Gao, Z., Liu, K., Tian, W., Wang, H., Liu, Z., Li, Y., Li, E., Liu, C., Li, X., Hou, R., Yue, C., Wang, D., Hu, Y., 2015. Effect of selenizing angelica polysaccharide and selenizing garlic polysaccharide on immune function of murine peritoneal macrophage. Int. J. Immunopharmacol. 27, 104 - 109." type="journal article" year="2015">Gao et al., 2015</bibRefCitation>
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). The Se-P was assayed in the concentration range from 0.781 μg/ mL to 3.125 μg/mL. Cells treated with the Se-P showed an enhanced phagocytosis and higher than that recorded upon treatment with the native polysaccharide. Also, NO release was increased by 30% at all doses tested, as well as the production of TNF-α (around 25%) and IL-6 (15%–20%), while IL-10 release underwent no substantial modification respect to controls. Finally, in 2017 Gao and coworkers assessed the
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<emphasis id="B9588266FF97FF84FD52D216FF483446" bold="true" italics="true" pageId="3" pageNumber="4">in vivo</emphasis>
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anti-oxidant and hepatoprotective effects of Se-Ps from Chinese angelica in CCl
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-induced hepatic injury in mice. These authors tested a Se-P with a Se content of
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/g and apply it in the concentration range
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<quantity id="4CD4F391FF97FF84FF3CD2E6FEC534EA" box="[159,261,1471,1490]" metricMagnitude="-8" metricUnit="kg" metricValue="6.26" pageId="3" pageNumber="4" unit="mg" value="0.0626">0.0626 mg</quantity>
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/g - 1.0 mg/g. In a preliminary screening
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<emphasis id="B9588266FF97FF84FD2FD2E6FD0B34EA" bold="true" box="[652,715,1471,1490]" italics="true" pageId="3" pageNumber="4">in vitro</emphasis>
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at all doses tested the Se-P showed a marked radical scavenging activity towards DPPH, hydroxyl radical, and superoxide anions displaying values comparable to those recorded for ascorbic acid used as the reference. In
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<emphasis id="B9588266FF97FF84FFC7D177FF5F3779" bold="true" box="[100,159,1582,1601]" italics="true" pageId="3" pageNumber="4">in vivo</emphasis>
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studies the Se-P was administered subcutaneously at three doses, namely
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/mL,
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<quantity id="4CD4F391FF97FF84FE94D113FEB73765" box="[311,375,1610,1629]" metricMagnitude="-7" metricUnit="kg" metricValue="1.0" pageId="3" pageNumber="4" unit="mg" value="0.1">0.1 mg</quantity>
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/mL, and
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<quantity id="4CD4F391FF97FF84FE78D113FDE63765" box="[475,550,1610,1629]" metricMagnitude="-7" metricUnit="kg" metricValue="1.5" pageId="3" pageNumber="4" unit="mg" value="0.15">0.15 mg</quantity>
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/mL once a day for 7 days. All groups of animals were then treated with CCl
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<quantity id="4CD4F391FF97FF84FDCAD137FD4A3741" box="[617,650,1638,1659]" metricMagnitude="-1" metricUnit="m" metricValue="1.016" pageId="3" pageNumber="4" unit="in" value="4.0">
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in
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olive oil i.p. to induce liver damage. The total protein content in this organ remained substantially unaffected in treated and control groups. However deep differences were noted for some key biochemical parameters. Pre-treatment with the Se-P at the medium and high doses led to a 2- to 3- fold reduction of ALT and AST, while a less effect was recorded on alkaline phosphatase respect to animals treated with only CCl
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. No appreciable histopathological changes were observed in animals pretreated with the Se-P, while huge infiltrations of inflammatory cells and fatty degeneration of hepatocytes were noted in control animals. Liver homogenate from animals administered the Se-P showed a reduced level of MDA, a very good ROS scavenging capacity, and a huge increase in the activity of CAT, SOD, and GSH. Finally, the expression extent of proteins being part of the MAPK signaling pathway, namely
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<emphasis id="B9588266FF97FF84FA1DD7C6FA08318A" bold="true" box="[1470,1480,159,178]" italics="true" pageId="3" pageNumber="4">p</emphasis>
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- ERK,
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<emphasis id="B9588266FF97FF84FCCBD7E2FCB231F6" bold="true" box="[872,882,187,206]" italics="true" pageId="3" pageNumber="4">p</emphasis>
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-JNK, and p38, was very close to that of animals treated only with the vehicle.
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</paragraph>
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</subSubSection>
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</treatment>
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</document> |