105 lines
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105 lines
12 KiB
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<document id="458300331B9BEA7AFEADDFAACDEC4C19" ID-DOI="10.1016/j.phytochem.2018.05.008" ID-ISSN="1873-3700" ID-Zenodo-Dep="10483984" IM.bibliography_approvedBy="felipe" IM.illustrations_approvedBy="felipe" IM.materialsCitations_approvedBy="juliana" IM.metadata_approvedBy="juliana" IM.taxonomicNames_approvedBy="juliana" IM.treatments_approvedBy="juliana" checkinTime="1704938445945" checkinUser="felipe" docAuthor="Fiorito, Serena, Epifano, Francesco, Preziuso, Francesca, Taddeo, Vito Alessandro & Genovese, Salvatore" docDate="2018" docId="0385EF62FF97FF84FC91D644FB7135F0" docLanguage="en" docName="Phytochemistry.153.1-10.pdf" docOrigin="Phytochemistry 153" docSource="http://dx.doi.org/10.1016/j.phytochem.2018.05.008" docStyle="DocumentStyle:9E596C34F4E94307D29315B03ACE1007.6:Phytochemistry.2014-2019.journal_article" docStyleId="9E596C34F4E94307D29315B03ACE1007" docStyleName="Phytochemistry.2014-2019.journal_article" docStyleVersion="6" docTitle="Chuanminshen violaceum M. L. Sheh & R. H. Shan" docType="treatment" docVersion="1" lastPageNumber="4" masterDocId="FFBC971AFF94FF87FFA3D759FFC03138" masterDocTitle="Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties" masterLastPageNumber="10" masterPageNumber="1" pageNumber="4" updateTime="1705322845058" updateUser="juliana">
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<mods:title id="91D5D4B241A6AC5084FC6A7F20EE4138">Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties</mods:title>
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<mods:namePart id="44FB5A7A47AD86D31DE8F4C65609B876">Fiorito, Serena</mods:namePart>
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<mods:affiliation id="1CEF028728D34506435D09134AF3C2F3">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy & Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia, Italy</mods:affiliation>
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<mods:namePart id="00C35A19C219436C6AF4D8E41A8A5E56">Epifano, Francesco</mods:namePart>
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<mods:affiliation id="2A08888E408850C444A92E71A3854564">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:nameIdentifier id="092C32F13129515F54CD6FB7540093D2" type="email">fepifano@unich.it</mods:nameIdentifier>
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<mods:namePart id="E9EA03F84DE5C01603307B885B82F0B5">Preziuso, Francesca</mods:namePart>
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<mods:affiliation id="28142391A836795346AE6793189FD687">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="D33B3C788CB909D81029EE9A321380FB">Taddeo, Vito Alessandro</mods:namePart>
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<mods:affiliation id="9F1A3E625C05CC39D93B024A69A11F78">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:namePart id="7EC402A1084582B7BABBC647B3A49147">Genovese, Salvatore</mods:namePart>
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<mods:affiliation id="CEC34C0A96716FB0C20838AB50F85998">Dipartimento di Farmacia, Università “ G. d’Annunzio ” of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy</mods:affiliation>
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<mods:title id="DF002A7F832FCE2A0DB7E29040332565">Phytochemistry</mods:title>
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<mods:date id="DC8B71C0215D2916219FB8F8ECD34B58">2018</mods:date>
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<mods:number id="DE19E251272969F4DE29BE8E37EA0B11">2018-09-30</mods:number>
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<mods:number id="F5D32DDC4D33DD31ADF774609C703908">153</mods:number>
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<mods:start id="59C13FA3D7BB91D26AEE1A3C682BFF31">1</mods:start>
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<mods:url id="AC3C8F52395ED1BAF76C69CB302C7910">http://dx.doi.org/10.1016/j.phytochem.2018.05.008</mods:url>
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<mods:classification id="F7C847AD5B7C76AF3BD928A136E6F0CD">journal article</mods:classification>
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<mods:identifier id="F957FD0E689B853A04CF289D3B0295BD" type="DOI">10.1016/j.phytochem.2018.05.008</mods:identifier>
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<mods:identifier id="BE55EBF1811326C50E2A20AADACB8765" type="ISSN">1873-3700</mods:identifier>
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<mods:identifier id="2AE00448EE6FE883C52B12413E1CF1A9" type="Zenodo-Dep">10483984</mods:identifier>
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<treatment id="0385EF62FF97FF84FC91D644FB7135F0" LSID="urn:lsid:plazi:treatment:0385EF62FF97FF84FC91D644FB7135F0" httpUri="http://treatment.plazi.org/id/0385EF62FF97FF84FC91D644FB7135F0" lastPageNumber="4" pageId="3" pageNumber="4">
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<subSubSection id="C3360DFFFF97FF84FC91D644FAF03008" box="[818,1328,285,304]" pageId="3" pageNumber="4" type="nomenclature">
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<paragraph id="8B935E74FF97FF84FC91D644FAF03008" blockId="3.[818,1328,285,304]" box="[818,1328,285,304]" pageId="3" pageNumber="4">
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<heading id="D0DBE918FF97FF84FC91D644FAF03008" bold="true" box="[818,1328,285,304]" fontSize="36" level="1" pageId="3" pageNumber="4" reason="1">
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<emphasis id="B9588266FF97FF84FC91D644FAF03008" bold="true" box="[818,1328,285,304]" italics="true" pageId="3" pageNumber="4">
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5.2.2.
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<taxonomicName id="4C2C25F7FF97FF84FCD1D644FAF03008" ID-CoL="V3JW" authority="M. L. Sheh & R. H. Shan" authorityName="M. L. Sheh & R. H. Shan" box="[882,1328,285,304]" class="Magnoliopsida" family="Apiaceae" genus="Chuanminshen" kingdom="Plantae" order="Apiales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="violaceum">Chuanminshen violaceum M.L. Sheh & R.H. Shan</taxonomicName>
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</emphasis>
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</heading>
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</paragraph>
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</subSubSection>
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<subSubSection id="C3360DFFFF97FF84FCF0D660FB7135F0" pageId="3" pageNumber="4" type="description">
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<paragraph id="8B935E74FF97FF84FCF0D660FB7135F0" blockId="3.[818,1488,313,1224]" pageId="3" pageNumber="4">
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<taxonomicName id="4C2C25F7FF97FF84FCF0D660FC093074" box="[851,969,313,332]" class="Magnoliopsida" family="Apiaceae" genus="Chuanminshen" kingdom="Plantae" order="Apiales" pageId="3" pageNumber="4" phylum="Tracheophyta" rank="species" species="violaceum">
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<emphasis id="B9588266FF97FF84FCF0D660FC093074" bold="true" box="[851,969,313,332]" italics="true" pageId="3" pageNumber="4">C. violaceum</emphasis>
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</taxonomicName>
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is a medicinal plant widespread in the Chinese provinces of
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<collectingRegion id="49E89096FF97FF84FC2CD60CFC193050" box="[911,985,341,360]" country="China" name="Sichuan" pageId="3" pageNumber="4">Sichuan</collectingRegion>
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and
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<collectingRegion id="49E89096FF97FF84FBADD60CFB8A3050" box="[1038,1098,341,360]" country="China" name="Hubei" pageId="3" pageNumber="4">Hubei</collectingRegion>
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. Its use is encoded in the Chinese traditional medicine practice. The polysaccharide fraction from this plant species is claimed to have positive modulatory effects on the immune system (
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<bibRefCitation id="EFBD2385FF97FF84FC20D6F1FBEA3083" author="Feng, H. & Fan, J. & Qiu, H. & Wang, Z. & Yan, Z. & Yuan, L. & Guan, L. & Du, X. & Song, Z. & Han, X. & Liu, J." box="[899,1066,424,443]" pageId="3" pageNumber="4" pagination="405 - 416" refId="ref10353" refString="Feng, H., Fan, J., Qiu, H., Wang, Z., Yan, Z., Yuan, L., Guan, L., Du, X., Song, Z., Han, X., Liu, J., 2015. Chuanminshen violaceum polysaccharides improve the immune responses of foot-and-mouth disease vaccine in mouse. Int. J. Biol. Macrobiol. 78, 405 - 416." type="journal article" year="2015">Feng et al., 2015</bibRefCitation>
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). Selenylation of polysaccharides from this species has been accomplished in 2016 by Feng and coworkers to obtain a single sample for which however no data about the Se content and yield have been reported. Subsequently the synthesized Se-P was tested for its capacity to enhance immune functions
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<emphasis id="B9588266FF97FF84FB4AD541FAE93313" bold="true" box="[1257,1321,536,555]" italics="true" pageId="3" pageNumber="4">in vitro</emphasis>
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and
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<emphasis id="B9588266FF97FF84FAFFD541FA583313" bold="true" box="[1372,1432,536,555]" italics="true" pageId="3" pageNumber="4">in vivo</emphasis>
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. First the effects on cell bioavailability were assayed on mice splenic lymphocytes. No cytotoxic activity up to a dose of 175 μg/mL were revealed. It is also noteworthy to underline that during this test an appreciable increase of the cell proliferation rate and production of IL-4 and IFN-γ were observed. These latter values were higher than those recorded for the group of cells treated with concanavalin A used as the reference.
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<emphasis id="B9588266FF97FF84FC3AD582FC1833D6" bold="true" box="[921,984,731,750]" italics="true" pageId="3" pageNumber="4">In vivo</emphasis>
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tests were carried out using ICR female mice pretreated with rHBsAg, and then administered the Se-P at a dose of 500 μg/mL by a daily subcutaneous injection for 2 weeks. At the end of the experiment (4 weeks) the following biochemical parameters were measured: induction of rHBsAg-specific IgG and effects on T cells proliferation, helper T cells, cytotoxic T lymphocytes, and NK cells. Respect to only vaccinated animals and animals treated with the native polysaccharide, a stronger enhancement of rHBsAg IgG1, IgG2a, and IgG2b contents have been recorded. Administration of the Se-P increased T cells proliferation rate although not at levels comparable to those induced by concanavalin A. The production of IL-2, IL-4, and IFN-γ by CD4
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<superScript id="7C59F33CFF97FF84FCF9D350FCAA352E" attach="left" box="[858,874,1033,1046]" fontSize="5" pageId="3" pageNumber="4">+</superScript>
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and CD8
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<superScript id="7C59F33CFF97FF84FC6BD350FC18352E" attach="left" box="[968,984,1033,1046]" fontSize="5" pageId="3" pageNumber="4">+</superScript>
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T cells was by far higher than all other groups of animals. As a parallelism Se-P treatment led to an increase and enforcement of the rHBsAg specific cytotoxic T lymphocytes capacity. In fact, the percentage of antigen-specific lysis of target cells in the Se-P group was 75.7%, while for mice treated with the parent polymer and in vaccinated only animals were 60.8% and 34.3% respectively. A similar pattern was recorded for NK cells.
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</paragraph>
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</subSubSection>
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</treatment>
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