129 lines
12 KiB
XML
129 lines
12 KiB
XML
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<mods:title id="7D78FDE093A4FBD140C2F0A020CAB203">Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10 a</mods:title>
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<mods:namePart id="256612BCE371776C0220FE25CD02FFA3">Eliwa, Duaa</mods:namePart>
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<mods:affiliation id="D401FBAD22E01C6B1D76779A0A213A61">* & National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, MS, 38677, USA & Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt</mods:affiliation>
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<mods:namePart id="D1B29BCF6383534330497F7CE7EE7B09">Albadry, Mohamed A.</mods:namePart>
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<mods:affiliation id="0687A18EFEE34B99199994787A6193D2">* & National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, MS, 38677, USA</mods:affiliation>
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<mods:namePart id="FC21B08D60D4ADBC44616C2840915A41">Ibrahim, Abdel-Rahim S.</mods:namePart>
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<mods:affiliation id="4100D8C232A84E02813651BBA419D5A7">Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt</mods:affiliation>
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<mods:namePart id="100F91C5DDEDE1BBCE03722F369290A1">Kabbash, Amal</mods:namePart>
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<mods:affiliation id="E95C9A6F6B7C74152CCE1A4DB823D658">Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt</mods:affiliation>
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<mods:namePart id="79E5DD6A940EEAE4CB726C47977280F6">Khan, Ikhlas A.</mods:namePart>
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<mods:affiliation id="B98F196406BCCEA325CA638413934279">* & National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, MS, 38677, USA & * & Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, University of Mississippi, MS, 38677, USA</mods:affiliation>
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<mods:namePart id="5B345BBEA8FAA4E529F60FFF520C797B">El-Aasr, Mona</mods:namePart>
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<mods:affiliation id="D53B01F29F9F5C41FDB41C074C875471">Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt</mods:affiliation>
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<mods:namePart id="29C3C459905741A41147F357C911CCF8">Ross, Samir A.</mods:namePart>
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<mods:affiliation id="81D223AD507DF24719731C4AAEC6B6D5">* & National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, MS, 38677, USA & * & Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, University of Mississippi, MS, 38677, USA</mods:affiliation>
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<mods:date id="D7656C8A338A084A291CA984B7687BA7">2021</mods:date>
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<mods:number id="701BECBA483A11008D2FB8FBB5871AA9">183</mods:number>
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<treatment id="03D387DCFFABFFC4CF0A8EC84174CB22" LSID="urn:lsid:plazi:treatment:03D387DCFFABFFC4CF0A8EC84174CB22" httpUri="http://treatment.plazi.org/id/03D387DCFFABFFC4CF0A8EC84174CB22" lastPageNumber="6" pageId="5" pageNumber="6">
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<subSubSection id="C3606541FFABFFC4CF0A8EC84754C86C" pageId="5" pageNumber="6" type="nomenclature">
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<emphasis id="B90EEAD8FFABFFC4CF0A8EC84754C86C" bold="true" italics="true" pageId="5" pageNumber="6">
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3.4. Microbial transformation using
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ATCC 18968
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Biotransformation of papaverine using
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<emphasis id="B90EEAD8FFABFFC4C8E18F7D41F6C81B" bold="true" box="[1241,1487,1348,1367]" italics="true" pageId="5" pageNumber="6">Cunninghamella echinulate</emphasis>
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ATCC 18968 produced one metabolite. The residue (
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) was dissolved in 30 ml of methanol/dichloromethane mixture (1:1) and adsorbed onto
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Celite and dried. The adsorbed sample was placed onto a glass column (110 ×
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) packed with silica after making a slurry in dichloromethane. The column was gradiently eluted with dichloromethane 100% then dichloromethane: methanol (98.5:1.5, 98:2) and 10 ml fractions were collected. Fractions 40–60 were pooled together to give compound
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<emphasis id="B90EEAD8FFABFFC4C8028C1A407FCB7A" bold="true" box="[1082,1094,1571,1590]" pageId="5" pageNumber="6">1</emphasis>
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. Further purification was achieved using sephadex LH-20 column, as determined by TLC. The metabolite was obtained in the form of white powder (
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,
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f
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).
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</treatment>
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