treatments-xml/data/03/D3/87/03D387DCFFA6FFC9CC5C8ED7473BCBE8.xml

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<mods:title id="AED455F0E17DA70FB05F673ADF059486">Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10 a</mods:title>
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<mods:namePart id="54C232538AF6816ECDE939AEA116E8B5">Eliwa, Duaa</mods:namePart>
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<treatment id="03D387DCFFA6FFC9CC5C8ED7473BCBE8" ID-DOI="http://doi.org/10.5281/zenodo.8302184" ID-GBIF-Taxon="212651920" ID-Zenodo-Dep="8302184" LSID="urn:lsid:plazi:treatment:03D387DCFFA6FFC9CC5C8ED7473BCBE8" httpUri="http://treatment.plazi.org/id/03D387DCFFA6FFC9CC5C8ED7473BCBE8" lastPageNumber="9" pageId="8" pageNumber="9">
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<heading id="D08D81A6FFA6FFC9CC5C8ED746A7C84D" bold="true" box="[100,670,1262,1281]" fontSize="36" level="1" pageId="8" pageNumber="9" reason="1">
<emphasis id="B90EEAD8FFA6FFC9CC5C8ED746A7C84D" bold="true" box="[100,670,1262,1281]" italics="true" pageId="8" pageNumber="9">
3.7. Microbial transformation using 
<taxonomicName id="4C7A4D49FFA6FFC9CD888ED74662C84D" ID-CoL="L5MZ" authority="(Bals.-Criv.) Vuill." authorityName="(Bals.-Criv.) Vuill." box="[432,603,1262,1281]" class="Sordariomycetes" family="Cordycipitaceae" genus="Beauveria" higherTaxonomySource="CoL" kingdom="Fungi" order="Hypocreales" pageId="8" pageNumber="9" phylum="Ascomycota" rank="species" species="bassiana">Beauveria bassiana</taxonomicName>
22864
</emphasis>
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<paragraph id="8BC536CAFFA6FFC9CCBC8F1F473BCBE8" blockId="8.[100,771,1317,1702]" pageId="8" pageNumber="9">
<location id="8EA56011FFA6FFC9CCBC8F1F4516C875" LSID="urn:lsid:plazi:treatment:03D387DCFFA6FFC9CC5C8ED7473BCBE8:8EA56011FFA6FFC9CCBC8F1F4516C875" box="[132,303,1318,1337]" county="The" latitude="-0.61" municipality="The" name="Biotransformation" pageId="8" pageNumber="9">Biotransformation</location>
of papaverine using 
<taxonomicName id="4C7A4D49FFA6FFC9CE328F1F4683C874" authority="(Bals.-Criv.) Vuill." authorityName="(Bals.-Criv.) Vuill." box="[522,698,1317,1337]" class="Sordariomycetes" family="Cordycipitaceae" genus="Beauveria" higherTaxonomySource="CoL" kingdom="Fungi" order="Hypocreales" pageId="8" pageNumber="9" phylum="Ascomycota" rank="species" species="bassiana">
<emphasis id="B90EEAD8FFA6FFC9CE328F1F4683C874" bold="true" box="[522,698,1317,1337]" italics="true" pageId="8" pageNumber="9">Beauveria bassiana</emphasis>
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22864 afforded to two metabolites: 
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and 
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. The residue (
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) was dissolved in 30 ml of methanol/dichloromethane mixture (1:1) and adsorbed onto 
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Celite and dried. The adsorbed sample was placed onto a glass column (110 × 
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) packed with silica after making a slurry in dichloromethane. The column was gradiently eluted with dichloromethane: methanol (99:1, 95:5,94:6) and 10 ml fractions were collected. 
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50–119 were pooled together to give mixture of the two metabolites (
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), as determined by TLC. The two metabolites were separated by preparative silica gel 60 PR-18 plates (10 × 
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, 250 μm) (methanol: water, 70:30). 
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of the sample added in each plate. The bands were located using UV lamp then scratched and extracted using 100% methanol then evaporated, yielding to pure 
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in
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the form of white powder (
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, 
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f 0.69 S 
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) and pure 
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white powder (
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, 
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f 0.61 S 
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).
</paragraph>
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</treatment>
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