130 lines
8.5 KiB
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130 lines
8.5 KiB
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@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
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@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
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@prefix bibo: <http://purl.org/ontology/bibo/> .
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@prefix cito: <http://purl.org/spar/cito/> .
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@prefix dc: <http://purl.org/dc/elements/1.1/> .
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@prefix dwc: <http://rs.tdwg.org/dwc/terms/> .
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@prefix dwcFP: <http://filteredpush.org/ontologies/oa/dwcFP#> .
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@prefix fabio: <http://purl.org/spar/fabio/> .
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@prefix trt: <http://plazi.org/vocab/treatment#> .
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@prefix xlink: <http://www.w3.org/1999/xlink/> .
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<http://treatment.plazi.org/id/7F122842D13AFFEAFFFDF8DDFAFEF82E>
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cito:cites <http://dx.doi.org/10.5281/zenodo.8240068>, <http://dx.doi.org/10.5281/zenodo.8240070>, <http://dx.doi.org/10.5281/zenodo.8240072>, <http://dx.doi.org/10.5281/zenodo.8240074>, <http://dx.doi.org/10.5281/zenodo.8240076>, <http://dx.doi.org/10.5281/zenodo.8240078> ;
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dc:creator "Vrabec, Rudolf; Ma, Jana; ríkov; a; Loc, Miroslav; arek; Kor, Jan; abe; cný; Hulcova, Daniela; Ho, Anna; st; alkov; a; Ji; Kune, rí; s; Chlebek, Jakub; Toma; Ku, s; cera; Hrabinova, Martina; Jun, Daniel; Ond; Soukup, rej; Andrisano, Vincenza; Jen, Jaroslav; co; Marcela; Safratova; Nov, Lucie; akova; Opletal, Lubomír; Cahlíkova, Lucie" ;
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dc:title "Vinca minor L." ;
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dwc:basisOfRecord <http://tb.plazi.org/GgServer/dwcaRecords/7F122842D13AFFEAFFFDF8DDFAFEF82E.mc.47D39309D138FFE0FCC8FE74FC55FC08> ;
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trt:publishedIn <http://dx.doi.org/10.1016/j.phytochem.2021.113017> ;
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trt:treatsTaxonName <http://taxon-name.plazi.org/id/Plantae/Vinca_minor> ;
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a trt:Treatment .
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<http://dx.doi.org/10.1016/j.phytochem.2021.113017>
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bibo:endPage "13" ;
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bibo:journal "Phytochemistry" ;
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bibo:pubDate "2022-02-28" ;
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bibo:series "113017" ;
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bibo:startPage "1" ;
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bibo:volume "194" ;
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dc:creator "Vrabec, Rudolf; Ma, Jana; ríkov; a; Loc, Miroslav; arek; Kor, Jan; abe; cný; Hulcova, Daniela; Ho, Anna; st; alkov; a; Ji; Kune, rí; s; Chlebek, Jakub; Toma; Ku, s; cera; Hrabinova, Martina; Jun, Daniel; Ond; Soukup, rej; Andrisano, Vincenza; Jen, Jaroslav; co; Marcela; Safratova; Nov, Lucie; akova; Opletal, Lubomír; Cahlíkova, Lucie" ;
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dc:date "2022" ;
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dc:title "Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer’s disease" ;
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fabio:hasPart <http://dx.doi.org/10.5281/zenodo.8240068>, <http://dx.doi.org/10.5281/zenodo.8240070>, <http://dx.doi.org/10.5281/zenodo.8240072>, <http://dx.doi.org/10.5281/zenodo.8240074>, <http://dx.doi.org/10.5281/zenodo.8240076>, <http://dx.doi.org/10.5281/zenodo.8240078> ;
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a fabio:JournalArticle .
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<http://taxon-name.plazi.org/id/Plantae/Vinca_minor>
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dwc:class "Magnoliopsida" ;
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dwc:family "Apocynaceae" ;
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dwc:genus "Vinca" ;
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dwc:kingdom "Plantae" ;
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dwc:order "Gentianales" ;
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dwc:phylum "Tracheophyta" ;
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dwc:rank "species" ;
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dwc:species "minor" ;
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trt:hasParentName <http://taxon-name.plazi.org/id/Plantae/Vinca> ;
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a dwcFP:TaxonName .
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<http://taxon-name.plazi.org/id/Plantae/Vinca>
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dwc:class "Magnoliopsida" ;
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dwc:family "Apocynaceae" ;
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dwc:genus "Vinca" ;
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dwc:kingdom "Plantae" ;
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dwc:order "Gentianales" ;
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dwc:phylum "Tracheophyta" ;
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dwc:rank "genus" ;
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trt:hasParentName <http://taxon-name.plazi.org/id/Plantae/Apocynaceae> ;
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a dwcFP:TaxonName .
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<http://taxon-name.plazi.org/id/Plantae/Apocynaceae>
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dwc:class "Magnoliopsida" ;
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dwc:family "Apocynaceae" ;
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dwc:kingdom "Plantae" ;
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dwc:order "Gentianales" ;
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dwc:phylum "Tracheophyta" ;
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dwc:rank "family" ;
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trt:hasParentName <http://taxon-name.plazi.org/id/Plantae/Gentianales> ;
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a dwcFP:TaxonName .
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<http://taxon-name.plazi.org/id/Plantae/Gentianales>
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dwc:class "Magnoliopsida" ;
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dwc:kingdom "Plantae" ;
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dwc:order "Gentianales" ;
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dwc:phylum "Tracheophyta" ;
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dwc:rank "order" ;
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trt:hasParentName <http://taxon-name.plazi.org/id/Plantae/Magnoliopsida> ;
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a dwcFP:TaxonName .
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<http://taxon-name.plazi.org/id/Plantae/Magnoliopsida>
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dwc:class "Magnoliopsida" ;
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dwc:kingdom "Plantae" ;
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dwc:phylum "Tracheophyta" ;
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dwc:rank "class" ;
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trt:hasParentName <http://taxon-name.plazi.org/id/Plantae/Tracheophyta> ;
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a dwcFP:TaxonName .
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<http://taxon-name.plazi.org/id/Plantae/Tracheophyta>
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dwc:kingdom "Plantae" ;
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dwc:phylum "Tracheophyta" ;
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dwc:rank "phylum" ;
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trt:hasParentName <http://taxon-name.plazi.org/id/Plantae> ;
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a dwcFP:TaxonName .
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<http://taxon-name.plazi.org/id/Plantae>
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dwc:kingdom "Plantae" ;
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dwc:rank "kingdom" ;
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a dwcFP:TaxonName .
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<http://dx.doi.org/10.5281/zenodo.8240068>
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dc:description "Fig. 1. Chemical structures of isolated alkaloids from aerial parts of Vinca minor." ;
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fabio:hasRepresentation <https://zenodo.org/record/8240068/files/figure.png> ;
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a fabio:Figure .
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<http://dx.doi.org/10.5281/zenodo.8240070>
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dc:description "Fig. 2. Indole alkaloids with a quebrachamine framework previously described in the literature employing at least 1H NMR analysis. The difference in the H-3 chemical shift of 3-epimers can be valuable for distinguishing between these diastereomers, which is highlighted. It must be mentioned that the C-3 configuration for all compounds shown was described to the contrary in Kutney’s article (Kutney et al., 1975). However, the correct configuration of these alkaloids had already been identified by Kompisˇet al. (1968)." ;
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fabio:hasRepresentation <https://zenodo.org/record/8240070/files/figure.png> ;
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a fabio:Figure .
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<http://dx.doi.org/10.5281/zenodo.8240072>
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dc:description "Fig. 3. Described key 2D NMR correlations of revision of previously assigned positions in molecule 17 (COSY interaction – red bond, HMBC interaction – blue arrow). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)" ;
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fabio:hasRepresentation <https://zenodo.org/record/8240072/files/figure.png> ;
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a fabio:Figure .
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<http://dx.doi.org/10.5281/zenodo.8240074>
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dc:description "Fig. 4. Steady state competitive type inhibition of hBuChE substrate hydrolysis by active compound 19 at different concentrations. Lineweaver Burk plots of initial velocity at increasing substrate concentrations (2.5–10.0 mM) are presented. Lines were derived from a linear regression of the data points. All measurements were made in triplicate and averaged." ;
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fabio:hasRepresentation <https://zenodo.org/record/8240074/files/figure.png> ;
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a fabio:Figure .
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<http://dx.doi.org/10.5281/zenodo.8240076>
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dc:description "Fig. 5. The top-scored docking poses of 19 in hBuChE (A, B; PDB ID: 4BDS) and the crystal structure of tacrine bound to hBuChE (C, D). The ligands are displayed in blue (A) and green (C) for 19 and tacrine, respectively; important amino acid residues responsible for ligand anchoring are shown in grey for hBuChE (A, C). Catalytic triad residues are displayed in yellow (A, C). Important interactions are rendered by black dashed lines; distances are measured in angstroms (Å). The rest of the receptor is displayed in light-grey cartoon conformation (A, C). Figures A and C were created with The PyMOL Molecular Graphics System, Version 2.4.1, Schr¨odinger, LLC. 2D figures (B, D) were generated with Maestro 12.3 (Schr¨odinger Release, Schr¨odinger, LLC, New York, NY, 2020). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)" ;
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fabio:hasRepresentation <https://zenodo.org/record/8240076/files/figure.png> ;
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a fabio:Figure .
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<http://dx.doi.org/10.5281/zenodo.8240078>
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dc:description "Fig. 6. Overlapped top-scored poses for ligands 19 (blue) and crystal structure of tacrine (green) in the active site of hBuChE (PDB ID: 4BDS). Amino acid residues involved in the interactions with ligands are depicted as either grey or yellow (catalytic triad) lines. The rest of the receptor is displayed in light-grey cartoon conformation. The Figure was created with The PyMOL Molecular Graphics System, Version 2.4.1, Schr¨odinger, LLC. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)" ;
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fabio:hasRepresentation <https://zenodo.org/record/8240078/files/figure.png> ;
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a fabio:Figure .
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<http://tb.plazi.org/GgServer/dwcaRecords/7F122842D13AFFEAFFFDF8DDFAFEF82E.mc.47D39309D138FFE0FCC8FE74FC55FC08>
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dwc:collectionCode "N, MS, IR, UV, H, NMR" ;
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trt:httpUri <https://treatment.plazi.org/id/7F122842D13AFFEAFFFDF8DDFAFEF82E#47D39309D138FFE0FCC8FE74FC55FC08> ;
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a dwc:MaterialCitation .
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